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Original Research

Open Access

Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer

  • M. J. Song1,*,
  • S. H. Lee1
  • M. R. Choi1
  • H. J. Son1
  • C. W. Lee1
  • J. H. Yoon1
  • Y. G. Park2
  • S. Y. Hur1
  • K. S. Ryu1
  • J. M. Lee1

1Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul

2Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul (Korea)

DOI: 10.12892/ejgo340208 Vol.34,Issue 2,March 2013 pp.148-151

Published: 24 March 2013

*Corresponding Author(s): M. J. Song E-mail: bitsugar@catholic.ac.kr

Abstract

Purpose: The aim of this study was to establish the guidelines for detecting early recurrences of advanced epithelial ovarian cancer by use of the CA-125 level. Materials and Methods: Eighty-five of the patients who met the inclusion criteria were enrolled in this study. The authors examined 25 incremental changes of CA125 from one to 25 IU/ml, and compared the CA-125 value with other prognostic factors. Increases in the CA-125 level from the nadir level were expressed as CA-125- increments. Results: Among the 25 increments, a CA-125-8 (eight IU/ml) was selected as the predictor that was the most efficient and time-effective. CA-125-8 had a sensitivity of 91.5%, a specificity of 84.6%, a positive predictive value of 93.1%, a negative predictive value of 81.5%, an efficiency of 89.4%. and a median lead-time of 68.5 days (p < 0.0001). Conclusion: The authors suggest the incremented CA-125-8 as a predictor of recurrent advanced ovarian cancer.

Keywords

Advanced ovarian cancer, CA-125; Early detection of recurrence.

Cite and Share

M. J. Song,S. H. Lee,M. R. Choi,H. J. Son,C. W. Lee,J. H. Yoon,Y. G. Park,S. Y. Hur,K. S. Ryu,J. M. Lee. Diagnostic value of CA125 as a predictor of recurrence in advanced ovarian cancer. European Journal of Gynaecological Oncology. 2013. 34(2);148-151.

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