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Original Research

Open Access

The regulation network and network motif analysis in ovarian cancer

  • A-juan Liang1
  • Yan Hong1
  • Yun Sun1
  • Min zhi Gao1,*,
  • Xiao ming Zhao1

1Department of Reproductive Medicine, Renji Hospital, Shanghai Jliaotong University, School of Medicine, Shanghai (China)

DOI: 10.12892/ejgo340214 Vol.34,Issue 2,March 2013 pp.170-174

Published: 24 March 2013

*Corresponding Author(s): Min zhi Gao E-mail: 328gao@sina.com

Abstract

Objective: Several gene alterations have been identified associated with ovarian cancer (OC) development. However, how these genetic elements are coordinated in transcription network during OC initiation and progression is poorly understood. Thus, the objective of this study was to interpret the transcription regulation network of OC. Materials and Methods: The GSE14407 microarray data was used for analysis of the transcription regulation network of OC. Results: The results showed that the TP53 (tumor protein p53) was the most crucial transcription factor in the transcriptome network. P53 could down-regulate CDC14A (CDC14 cell division cycle 14 homolog A [S. cerevisiae]) and FAS (TNF receptor superfamily, member 6) expression, but up-regulate SFN (stratifin) and THBS1 (thrombospondin 1) expression to involve in pathways in cancer, cell cycle, p53 signaling pathway, and apoptosis pathway. Conclusion: This transcriptional regulation may provide a better understanding of molecular mechanism and some potential therapeutic targets in the treatment of OC.

Keywords

Regulation network; Network motif analysis; Ovarian cancer.

Cite and Share

A-juan Liang,Yan Hong,Yun Sun,Min zhi Gao,Xiao ming Zhao. The regulation network and network motif analysis in ovarian cancer. European Journal of Gynaecological Oncology. 2013. 34(2);170-174.

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