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Original Research

Open Access

Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell

  • N. A. Abdullah1
  • P. N. Wang2
  • K. G. Huang3,*,
  • A. S. Adlan4
  • J. Casanova5

1Department of Obstetrics & Gynecology, Sultanah Bahiyah Hospital, Kedah (Malaysia)

2Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan (Taiwan)

3Department of Obstetrics and Gynecology Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kwei-Shan, Tao-Yuan (Taiwan)

4Department of Obstetrics and Gynecology. University Malaya Medical Center, Faculty of Medicine, University of Malaya, Kuala Lumpur (Malaysia)

5Department of Obstetrics & Gynecology, Centro Hospitalar do Porto, Porto (Portugal)

DOI: 10.12892/ejgo340217 Vol.34,Issue 2,March 2013 pp.183-185

Published: 24 March 2013

*Corresponding Author(s): K. G. Huang E-mail:


A 21-year-old lady diagnosed with Stage 3 ovarian yolk sac tumor (YST) underwent primary cytoreductive fertility sparing surgery, followed by conventional courses of platinum-based chemotherapy and etoposide. Recurrence at cul-da-sac was noted after a short period of remission and secondary debulking performed followed by four cycles of conventional chemotherapy. The patient’s disease progressed despite courses of treatments. A joint team management including a hematologist was commenced following the failure of conventional chemotherapies. Two cycles of high-dose chemotherapy (HDCT) with ifosfamide/cisplatin/etoposide (ICE) regimen, followed by autologous stem cell transplantation (ASCT) were given. With this salvage treatment, she remained in complete remission and disease-free for more than 30 months, while maintaining her reproductive function. These approaches appear to be effective as a salvage treatment in selected cases of patients with ovarian germ cell tumor, especially those who failed primary conventional chemotherapy.


High-dose chemotherapy; Germ cell tumor; Autologous stem cell.

Cite and Share

N. A. Abdullah,P. N. Wang,K. G. Huang,A. S. Adlan,J. Casanova. Sustainable complete remission in recurrence yolk sac tumor patient treated with tandem high-dose chemotherapy and autologous stem cell. European Journal of Gynaecological Oncology. 2013. 34(2);183-185.


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