Ovarian gastrointestinal stromal tumor: does this diagnosis exist

Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal (GI ) tract tumors. Those tumors rarely arise extra intestinally; within omentum, mesentery, and rarely uterus. The authors report a case of myxoid variant of GIST arising in the ovary with no evidence of a primary tumor in the GI tract. Surgeons as well as gynecologists should bear this possibility in mind when managing pelvic masses.

Ovarian tumor; Gastrointestinal stromal tumor; Myxoid variant of GIST; Imatinib resistance.

[1] Lucas D.R.: “Clinicopathology and molecular diagnostics of gastrointestinal stromal tumors”. Curr. Probl. Cancer, 2011, 35, 233.

[2] Demetri G.D., Von Mehren M., Antonescu C.R., DeMatteo R.P., Ganjoo K.N., Maki R.G., et al.: “NCCN task force report: update on the management of patients with gastrointestinal stromal tumors”. J. Natl. Compr. Cancer Network, 2010, 8, S1.

[3] Pinto V., Ingravallo G., Cicinelli E., Pintucci A., Sambati G.S., Marinaccio M., D'Addario V.: “Gastrointestinal stromal tumors mimicking gynecological masses on ultrasound: a report of two cases”. Ultrasound Obstet. Gynecol., 2007, 30, 359.

[4] Irving J.A., Lerwill M.F., Young R.H.: “Gastrointestinal stromal tumors metastatic to the ovary: a report of five cases”. Am. J. Surg. Pathol., 2005, 29, 920.

[5] Carlomagno G., Beneduce P.: “A gastrointestinal stromal tumor (GIST) masquerading as an ovarian mass”. World J Surg Oncol., 2004, 2, 15.

[6] Yayci E., Guler O.T., Kuzey G.M., Comuoglu C., Atacag T., Cetin A., et al.: “Gastrointestinal stromal tumor mimicking gynecological mass: a case report”. Gynecol. Oncol. Rep., 2012, 2, 107.

[7] Joensuu H.: “Gastrointestinal stromal tumor (GIST)”. Ann. Oncol., 2006, 17, 280.

[8] Sakurai S., Hasegawa T., Sakuma Y., Takazawa Y., Motegi A., Nakajima T., et al.: “Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: A subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene”. Hum. Pathol., 2004, 35, 1223.

[9] Agaimy A., Lindner M., Wuensch P.H.: “Interstitial cells of Cajal (ICC) in mature cystic teratoma of the ovary”. Histopathology, 2006, 48, 208.

[10] Agaimy A., Wünsch P.H.: “Coexistence of interstitial cell of Cajal hyperplasia and microcarcinoidosis in a mature cystic teratoma of the ovary”. Histopathology, 2008, 52, 260.