Article Data

  • Views 508
  • Dowloads 128

Original Research

Open Access

Gestational trophoblastic disease in Campinas, Brazil and persistency predictors

  • D.A. Yela1,*,
  • M.L. dos Anjos Prado1
  • A.L. Leite Ribeiro Freire1
  • C. Laguna Benetti-Pinto1

1Department of Obstetrics and Gynecology, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

DOI: 10.12892/ejgo3432.2017 Vol.38,Issue 1,February 2017 pp.91-94

Published: 10 February 2017

*Corresponding Author(s): D.A. Yela E-mail: yela@unicamp.br

Abstract

Purpose: To determine the prevalence of the gestational trophoblastic disease (GTD) and to evaluate the risk factors for persistence of the disease. Materials and Methods: A retrospective study with 152 women diagnosed with GTD at University of Campinas from 2006 to 2013. Frequencies, average, and standard deviation were evaluated for each variable and an exact Fisher test was utilized to study persistent disease risk factors. Results: The women were on average 25.81 ± 8.02 years old. The most prevalent blood type was O positive (49.6%). The diagnosis of complete mole was found in 64.8%, followed by partial mole in 32%, and choriocarcinoma in 3%. Complete mole developed invasive mole in 12.3%, the same occurred with 7.5% of the partial moles. No significant association was found between age, number of gestations, race, BMI or blood type and persistent mole. Conclusion: The complete mole is the most frequent GTD, and is at high risk for developing malignant forms.

Keywords

Gestational trophoblastic disease; Persistent gestational trophoblastic disease; Hydatidiform mole.

Cite and Share

D.A. Yela,M.L. dos Anjos Prado,A.L. Leite Ribeiro Freire,C. Laguna Benetti-Pinto. Gestational trophoblastic disease in Campinas, Brazil and persistency predictors. European Journal of Gynaecological Oncology. 2017. 38(1);91-94.

References

[1] Sun S.Y., Amed A.M., Bertini A.M., Camano L.: “Incidencia de mola hidatiforme na Escola Paulista de Medicina”. Rev. Assoc. Med. Bras., 1992, 38, 217.

[2] Lybol C., Thomas C.M.G., Bulten J., Van Dijck J.A.A.M., Sweep F.C.G.J., Massurger L.F.A.G.: “Increase in the incidence os gestational disease in The Netherlands”. Gynecol. Oncol., 2011, 121, 334.

[3] Altieri A., Franceschi S., Ferlay J., Smith J., La Vecchia C.: “Epidemiology and aetiology of gestational trophoblastic diseases”. Lancet Oncol., 2003, 4, 670.

[4] Soares P.D., Maesta I., Costa O.L., Charry R.C., Dias A., Rudge M.V.: “Geographical distribuition and demographic characteristics of gestational trophoblastic disease”. J. Reprod. Med., 2010, 55, 305.

[5] Cheung A.N.: “Pathology of gestational trophoblastic diseases”. Best Pract. Res. Clin. Obstet. Gynaecol., 2003, 17, 849.

[6] Bagshawe K.D., Dent J., Webb J.: “Hydatiform mole in England and Wales 1973-83”. Lancet, 1986, 2, 6763.

[7] Soper J.T.: “Management of gestationaltrophoblasticdisease”. Oncology (Williston Park), 1993, 7, 68.

[8] Lurain J.R., Brewer J.I., Torok E.E., Halpern B.: “Natural history of hydatidiform mole afterprimaryevacuation”. Am. J. Obstet. Gynecol., 1983, 145, 591.

[9] Nakano R., Sasaki K., Yamoto M., Hata H.: “Trophoblasticdisease: analysis of 342 patients”. Gynecol. Obstet. Invest., 1980, 11, 237.

[10] Smith H.O.: “Gestational trophoblastic disease epidemiology and trends”. Clin. Obstet. Gynecol., 2003, 46, 541.

[11] Hancock B.W.: “Staging and classification of gestational trophoblastic disease”. Best Pract. Res. Clin. Obstet. Gynaecol., 2003, 17, 869.

[12] Tiezzi D.G., Andrade J.M., Reis F.J.C., Lombardi W., Marana H.R.C.: “Fatores de risco para doença trofoblástica gestacional persistente”. Rev. Bras. Ginecol. Obstet., 2005, 27, 331.

[13] Bandy L.C., Clarke-Pearson D.L., Hammond C.B.: “Malignant potential of gestational trophoblastic disease at the extreme ages of reproductive life”. Obstet. Gynecol., 1984, 64, 395.

[14] Brinton L.A., Bracken M.B., Connelly R.R.: “Choriocarcinoma incidence in the United States”. Am. J. Epidemiol., 1986, 123, 1094.

[15] Mungan T., Kuscu E., Dabakoglu T., Senoz S., Ugur M., Cobanoglu O.: “Hydatidiform mole: clinical analysis of 310 patients”. Int. J. Gynecol. Obstet., 1996, 52, 233.

[16] Maesta I., Rudge M.V.C., Abreu E.S., Dalben I., Peraçoli J.C.: “ Preditores clínicos e histopatológicos de tumor trofoblastico gestacional pós-mola hidatiforme completa”. Rev. Bras. Ginecol. Obstet., 2000, 22, 167.

[17] Hertig A.T., Mansell H.: “Hydatidiform mole and choriocarcinoma”. In: Tumors of the female sex organs. Part I, Atlas of Tumor Pathology, section 9, fasc. 33. Washington, DC: Armed Forces Institute of Pathology, 1956, 7.

[18] Delfs E.: “Chorionic gonadotropin determinations with hydatidiform mole and choriocarcinoma”. Ann. N. Y. Acad. Sci., 1959, 8, 125.

[19] Feltmate C.M., Batorfi J., Fulop V., Goldstein D.P., Doszpod J., Berkowitz R.S.: “Human chorionic gonadotropin follow-up in patients with molar pregnancy: a time for reevaluation”. Obstet. Gynecol., 2003, 101, 732.

[20] Morrow C.P., Kletzky O.A., Disaia P.J., Townsend D.E., Mishell D.R., Nakamura R.M.: “Clinical and laboratory correlates of molar pregnancy and trophoblastic disease”. Am. J. Obstet. Gynecol., 1977, 128, 424.

[21] Pisal N., Tidy J., Hancock B.: “Gestational trophoblastic disease: is intensive follow up essential in all women?” BJOG, 2004, 111, 1449.

[22] Soper J.T.: “Staging and evaluation of gestational trophoblastic disease”. Clin. Obstet. Gynecol., 2003, 46, 570.

[23] Bracken M.B., Brinton L.A., Hayashi K.: “Epidemiology of hydatidiform mole and choriocarcinoma”. Epidemiol. Rev., 1984, 6, 52.

[24] World Health Organization (WHO), Scientific Group on Gestational Trophoblastic Disease: “Gestational trophoblastic diseases, Technical Report Series, 692”. Geneva: WHO, 1983. Available at: http://apps.who.int/iris/bitstream/10665/39169/1/WHO_TRS_692.pdf

[25] Goldstein D.P., Berkowitz R.S., Bernstein M.R.: “Management of molar pregnancy”. J. Reprod. Med., 1981, 26, 208.

[26] Curry S.L., Hammond C.B., Tyrey L., Creasman W.T., Parker R.T.: “Hydatidiform mole: diagnosis management, and long-term followup of 347 patients”. Obstet. Gynecol., 1975, 45, 1.

[27] Park T.K., Kim S.N., Lee S.K.: “Analysis of risk factors for postmolar trophoblastic disease: categorization of risk factors and effect of prophylactic chemotherapy”. Yonsei Med. J., 1996, 37, 412.

[28] Tangtrakul S., Srisupundit S., Linasmita V., Bullangpoti S., Bhamarapravati Y.: “The risk factors in the development of persistent trophoblastic disease following hydatidiform mole”. J. Med. Assoc. Thai, 1990, 73, 33.

[29] Yazaki-Sun S., Monteleone P.P.R., Bertini A.M., Camano L.: “A importância da idade da paciente no prognóstico da mola hidatiforme”. Ars. Cvrandi, 1992, 25, 34.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top