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Seminoma leading to detection of testicular feminization syndrome: a case report

  • S. Nakamura1
  • H. Tsujioka1,*,
  • T. Fukami1
  • M. Goto1
  • R. Matsuoka1
  • F. Eguchi1

1Department of Obstetrics and Gynecology, Iizuka Hospital, Iizuka, Fukuoka, Japan

DOI: 10.12892/ejgo3435.2017 Vol.38,Issue 1,February 2017 pp.153-156

Published: 10 February 2017

*Corresponding Author(s): H. Tsujioka E-mail: htsujiokah1@aih-net.com

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Abstract

The authors here report a 54-year-old (gravida 0, para 0), who claimed to have had her menarche at age 13 and menopause at 52 years. Two months prior to presentation, the subject first noticed a hard but elastic fist-sized mass in the left inguinal region that gradually grew, causing pressure-related pain. Although the external genitalia appeared female, the vagina was short and blind-ending, and no uterus or ovaries were identified on transvaginal ultrasound. Chromosome banding results (G-band method) showed 46XY. Laparoscopy revealed no traces of a vestigial uterus or ovaries; thus, based on the appearance of the external genitalia, a diagnosis of testicular feminization syndrome was made. Pathological testing of the palpable mass led to a diagnosis of seminoma with Leydig cell hyperplasia. Thus, in this case, the development of a seminoma in an undescended testis led to the detection of testicular feminization syndrome.

Keywords

Seminoma; Testicular feminization syndrome; External genitalia.

Cite and Share

S. Nakamura,H. Tsujioka,T. Fukami,M. Goto,R. Matsuoka,F. Eguchi. Seminoma leading to detection of testicular feminization syndrome: a case report. European Journal of Gynaecological Oncology. 2017. 38(1);153-156.

URL:

https://www.ejgo.net/articles/10.12892/ejgo3435.2017

References

[1] Morris J.M., Conn N.H. “The syndrome of testicular feminization in male pseudohermaphrodites”. Am. J. Obstet. Gynecol., 1953, 65, 1192–1211.

[2] Imura, H., Matsumoto, K., Ogata, E., Yoshida S., Igarashi Y., Kono T., Matsukura S.: “Hormone receptor diseases” in Japan: A nation-wide survey for testicular feminization syndrome, pseudohypoparathyroidism, nephrogenic diabetes insipidus, Bartter's syndrome and congenital adrenocortical unresponsiveness to ACTH (author's transl)”. Nihon Naibunpi Gakkai Zasshi, 1980, 56, 1031. [Article in Japanese]

[3] Yamaguchi M., Yanagida K., Mori N.: “A case of complete testicular feminization syndrome”. Clin. Endocrinol. (Oxf.), 1991, 39, 51.

[4] Copeland L.J., Jarrell J.F.: “Textbook of Gynecology”. 2nded. Philadelphia, PA: W.B. Saunders Co., 2000, 562.

[5] Manuel M., Katayama K.P., Jones H.W. Jr.: “The age of occurrence of gonadal tumors in intersex patients with a Y chromosome”. Am. J. Obstet. Gynecol. 1976, 124, 293.

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