Article Data

  • Views 514
  • Dowloads 132

Original Research

Open Access

A preliminary study for the treatment of cervical colposcopic lesions with the biological compound AV2

  • G. Martinez1,*,
  • B.A. Mutombo2
  • V. Fernandez1
  • J.P. Van Geertruyden3
  • J.P. Van Geertruyden4

1Hospital de la Familia, Juarez, Mexico

2University of Kinshasa, Department of Obstetrics and Gynecology, Kinshasa, Democratic Republic of the Congo

3University of Antwerp, International Health Unit, Antwerp, Belgium

4University of Antwerp, Department of Obstetrics and Gynecology, Antwerp, Belgium

DOI: 10.12892/ejgo3436.2017 Vol.38,Issue 3,June 2017 pp.342-345

Published: 10 June 2017

*Corresponding Author(s): G. Martinez E-mail: alexmutombo@gmail.com

Abstract

Objective: To evaluate the efficacy of AntiViral 2 (AV2) in the regression of moderate and severe colposcopic lesions, when compared to placebo. Materials and Methods: Women, aged over 18 years with a colposcopic diagnosis of moderate to severe dysplasia were randomized to receive either two applications of AV2 or placebo within four days. Both examining physician and patients were blinded to the treatment option. Follow-up colposcopy was performed on days 11, 21, and 60. Results: A total of 50 patients were enrolled in this study. There was no statistically significant difference in screening entry criteria between the two groups. The results showed that the application of AV2 yielded a reduction of more than 50% for 21 out of 28 (75%) patients who received the active treatment versus a 0% for the comparable placebo group (p < 0.001). Conclusions: The authors conclude that AV2 can have a place in the treatment of colposcopically-detected cervical lesions. Due to the proven broad spectrum antiviral activity of AV2, a plausible explanation is that the lesions regress due to deactivation of the virus. Further trials with larger numbers and detailed cytology and histology are needed to confirm these results.

Keywords

Cervical lesion; Colposcopy; Human papillomavirus; AV2; Essential oil; Treatment.

Cite and Share

G. Martinez,B.A. Mutombo,V. Fernandez,J.P. Van Geertruyden,J.P. Van Geertruyden. A preliminary study for the treatment of cervical colposcopic lesions with the biological compound AV2. European Journal of Gynaecological Oncology. 2017. 38(3);342-345.

References

[1] Bosch F.X., Munoz N.: “The viral etiology of cervical cancer”. Virus Res., 2002, 89, 183.

[2] Ferlay J., Shin H.R., Bray F., Forman D., Mathers C., Parkin D.M.: “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008”. Int. J Cancer, 2010, 127, 2893.

[3] Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J.: “Cancer statistics, 2009”. CA Cancer J. Clin., 2009, 59, 225.

[4] Kersemaekers A.M., Fleuren G.J., Kenter G.G., Van den Broek L.J., Uljee S.M., Hermans J., Van de Vijver M.J.: “Oncogene alterations in carcinomas of the uterine cervix: overexpression of the epidermal growth factor receptor is associated with poor prognosis”. Clin. Cancer Res., 1999, 5, 577.

[5] Saraiya M., Berkowitz Z., Yabroff K.R., Wideroff L., Kobrin S., Benard V.: “Cervical cancer screening with both human papillomavirus and Papanicolaou testing vs Papanicolaou testing alone: what screening intervals are physicians recommending?” Arch. Intern. Med., 2010, 170, 977.

[6] Massad L.S., Einstein M.H., Huh W.K., Katki H.A., Kinney W.K., Schiffman M., et al.: “2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstet. Gynecol., 2013, 121, 829.

[7] Schiffman M., Castle P.E., Jeronimo J., Rodriguez A.C., Wacholder S.: “Human papillomavirus and cervical cancer”. Lancet, 2007, 370, 890.

[8] Cesa Alliance: Available at: http://www.cesa-alliance.com/webapp/index.html

[9] Chaieb K, Hajlaoui H, Zmantar T, Kahla-Nakbi AB, Rouabhia M, Mahdouani K, Bakhrouf A: The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother Res., 2007, 21, 501.

[10] Shoji Y., Ishige H., Tamura N., Iwatani W., Norimatsu M., Shimada J., Mizushima Y.: “Enhancement of anti-herpetic activity of antisense phosphorothioate oligonucleotides 5’ end modified with geraniol”. J. Drug Target., 1998, 5, 261.

[11] Guido R., Lonky N.M., Diedrich J.: “Secondary prevention of cervical cancer part 3: evidence-based management of women with cervical intraepithelial neoplasia”. Clin. Obstet. Gynecol., 2014, 57, 302.

[12] Yi J.L., Shi S., Shen Y.L., Wang L., Chen H.Y., Zhu J., Ding Y.: “Myricetin and methyl eugenol combination enhances the anticancer activity, cell cycle arrest and apoptosis induction of cis-platin against HeLa cervical cancercell lines”. Int. J. Clin. Exp. Pathol., 2015, 8, 1116.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top