Lynch syndrome in patients treated for endometrial cancer

Objective: To evaluate the patients with familial Lynch syndrome, who were treated for endometrial cancer in Gynecology Department of Ankara Oncology Education and Research Hospital. Materials and Methods: Staging surgery was performed in all patients diagnosed with endometrial cancer. Total abdominal hysterectomy (TAH), bilateral salpingo-oophorectomy (BSO), omentectomy, bilateral pelvic-para-aortic lymph node dissection (BPPLND), and peritoneal cytology were performed. The patients were referred to radiation oncology clinic with their final pathology report, postoperatively. Adjuvant radiotherapy was performed in patients deemed necessary. Results: Familial Lynch syndrome was detected in four of 93 patients. All of the Lynch cases were diagnosed with FIGO Stage I endometrial adenocarcinoma. The mean age of Lynch syndrome patients was 51.5 years. Two of these 93 patients were synchronous colon and endometrial cancer and one of these 93 patients was metachronous colon and endometrial cancer, but Lynch syndrome was not diagnosed in these three patients according to Amsterdam criteria. Conclusion: Diagnosis of patients with Lynch syndrome and identification of at-risk people is very important because if it is diagnosed at early stage, better survival rates could be expected.

Lynch syndrome; Endometrial cancer; Colon cancer.

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