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Original Research

Open Access

Expression and association of reproductive hormones and receptors in postmenopausal patients with breast cancer

  • D.H. Zou1
  • X.M. He1
  • B. Chen2
  • X.H. Xu3
  • X.P. Zhang1
  • J.F. Ni1
  • W.M. Mao4,*,

1Department of Breast Surgery, The Centre of Chest Oncology, Zhejiang Cancer Hospital, Hangzhou, China

2Pathology Department, The Centre of Chest Oncology, Zhejiang Cancer Hospital, Hangzhou, China

3Clinic Laboratory, The Centre of Chest Oncology, Zhejiang Cancer Hospital, Hangzhou, China

4Department of Thoracic Surgery, The Centre of Chest Oncology, Zhejiang Cancer Hospital, Hangzhou, China

DOI: 10.12892/ejgo3694.2017 Vol.38,Issue 5,October 2017 pp.727-732

Published: 10 October 2017

*Corresponding Author(s): W.M. Mao E-mail: weimin_mao@sina.com

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Abstract

Background: Reproductive hormones and receptors play a crucial role in the development and progression of breast cancer. Materials and Methods: In the present study, the authors determined expression and association of reproductive hormones and receptors in 352 postmenopausal (PMP) patients with breast cancer. Results: The authors found that serum level of luteinizing hormone (LH) declined as PMP years progressed in this patient cohort. The median value of LH was significantly higher in patients within five years of PMP (23 mIU/ml) than patients with PMP beyond five years (18.32 mIU/ml, p < 0.0001). The numbers of strong expression of estrogen receptor (ER) and progesterone receptor (PR) were significantly higher in patients within five years of PMP (103 and 93 cases, respectively) than patients with PMP beyond five years (61 and 46 cases, p = 0.019 and p = 0.0005, respectively). While most patients either lacked (97.1%) or coexpressed (84.3%) both ER and PR, a substantial number of patients expressed either ER or PR alone. Expression of ER and PR was negatively associated with HER2 expression in PMP patients with breast cancer. The present authors observed that increased expression levels of ER and PR were associated with a decline of serum levels of LH or follicle-stimulating hormone (FSH). Conclusion: These results indicated that PMP-mediated decrease in LH and FSH serum level was associated with increased expression level of ER and PR, as well as a decreased expression level of HER2 in patients with breast cancer.

Keywords

Breast cancer; Postmenopause; Reproductive hormones; Estrogen receptor; Progesterone receptor; HER2 receptor.

Cite and Share

D.H. Zou,X.M. He,B. Chen,X.H. Xu,X.P. Zhang,J.F. Ni,W.M. Mao. Expression and association of reproductive hormones and receptors in postmenopausal patients with breast cancer. European Journal of Gynaecological Oncology. 2017. 38(5);727-732.

URL:

https://www.ejgo.net/articles/10.12892/ejgo3694.2017

References

[1] Jemal F., Bray M.M., Center J., Ferlay E., Ward D., Forman D.: “Global cancer statistics”. Cancer J. Clin., 2011, 61, 69.

[2] Anderson K.N., Schwab R.B., Martinez M.E.: “Reproductive risk factors and breast cancer subtypes: a review of the literature”. Breast Cancer Res. Treat., 2014, 144, 1.

[3] Yager J.D., Davidson N.E.: “Estrogen carcinogenesis in breast cancer”. N. Engl. J. Med., 2006, 354, 270.

[4] Missmer S.A., Eliassen A.H., Barbieri R.L., Hankinson S.E.: “Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women”. J. Natl. Cancer Inst., 2004, 96, 1856.

[5] Miyoshi Y., Tanji Y., Taguchi T., Tamaki Y., Noguchi S.: “Association of serum estrone levels with estrogen receptor-positive breast cancer risk in postmenopausal Japanese women”. Clin. Cancer Res., 2003, 9, 2229.

[6] Mohammed R.H., Lakatua D.J., Haus E., Yasmineh W.J.: “Estrogen and progesterone receptors in human breast cancer. Correlation with histologic subtype and degree of differentiation”. Cancer, 1986, 58, 1076.

[7] Ménard S., Casalini P., Campiglio M., Pupa S.M., Tagliabue E.: “Role of HER2/neu in tumor progression and therapy”. Cell Mol. Life Sci., 2004, 61, 2965.

[8] Krishnamurti U., Silverman J.F.: “HER2 in breast cancer: a review and update”. Adv. Anat. Pathol., 2014, 21, 100.

[9] Cordera F., Jordan V.C.: “Steroid receptors and their role in the biology and control of breast cancer growth”. Semin. Oncol., 2006, 33, 631.

[10] Podo F., Buydens L.M., Degani H., Hilhorst R., Klipp E., Gribbestad I.S., et al.: “Triple-negative breast cancer: present challenges and new perspectives”. Mol. Oncol., 2010, 4, 209.

[11] Goldzieher M.A.: “Treatment of excessive growth in the adolescent female”. J. Clin. Endocrinol. Metab., 1956, 16, 249.

[12] Ritzen E.M., Nilsson O., Grigelioniene G., Holst M., Savendahl L., Wroblewski J.: “Estrogens and human growth”. J. Steroid Biochem. Mol. Biol., 2000, 74, 383.

[13] Althuis M.D., Fergenbaum J.H., Garcia-Closas M., Brinton L.A., Madigan M.P., Sherman M.E.: “Etiology of hormone receptor-defined breast cancer: a systematic review of the literature”. Cancer Epidemiol. Biomarkers Prev., 2004, 13, 1558.

[14] Payne S.J.L., Bowen R.L., Jones J.L., Wells C.A.: “Predictive markers in breast cancer: the present”. Histopathology, 2008, 52, 82.

[15] Nadji M., Gomez-Fernandez C., Ganjei-Azar P., Morales A.R.: “Immunohistochemistry of estrogen and progesterone receptors reconsidered: experience with 5,993 breast cancers”. Am. J. Clin. Pathol., 2005, 123, 9.

[16] Rakha E.A., El-Sayed M.E., Green A.R., Paish E.C., Powe D.G., Gee J., et al.: “Biologic and clinical characteristics of breast cancer with single hormone receptor-positive phenotype”. J. Clin. Oncol., 2007, 25, 4772.

[17] Huang H.J., Neven P., Drijkoningen M., Paridaens R., Wildiers H., Van Limbergen E., et al.: “Association between tumour characteristics and HER2/neu by immunohistochemistry in 1,3 women with primary operable breast cancer”. J. Clin Pathol., 2005, 58, 611.

[18] Martin M.B., Saceda M., Lindsey R.K.: “Regulation of estrogen receptor expression in breast cancer”. Adv. Exp. Med. Biol., 1993, 330, 143.

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