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Chemotherapy improves survival rate in Stage 1 ovarian cancers

  • L. Dewick1,*,
  • J. Raut1
  • V. Asher1

1Department of Obstetrics & Gynaecology, Royal Derby Hospital, Derby (United Kingdom)

DOI: 10.12892/ejgo3715.2018 Vol.39,Issue 1,February 2018 pp.49-52

Published: 10 February 2018

*Corresponding Author(s): L. Dewick E-mail: louisedewick@nhs.net

Abstract

Purpose of Investigation: The role of adjuvant chemotherapy in Stage 1 ovarian cancer is conflicting with no clear evidence to support adjuvant chemotherapy versus observation alone. The authors sought to establish the survival benefit of adjuvant chemotherapy in all Stage 1 ovarian cancers. Materials and Methods: Retrospective data including age, stage, grade, histology, RMI, and chemotherapy status on all patients undergoing treatment for Stage 1 ovarian cancer between May 2003 and November 2013 at Royal Derby Hospital was collected. Results: Eighty-nine cases of Stage 1 ovarian cancer were included. A total of 73 patients (84.88%) received adjuvant chemotherapy while 13 (15.12%) did not. The patients receiving adjuvant chemotherapy had a median overall survival (OS) of 108 months (CI 99.07−118.33) while the median OS for the patients who did not receive any adjuvant treatment was 63.71 months (CI 43.06−83.35) p = 0.003. Conclusion: Adjuvant chemotherapy significantly improves OS in Stage 1 ovarian cancer patients.

Keywords

Ovarian cancer; Stage 1; Adjuvant; Chemotherapy.

Cite and Share

L. Dewick,J. Raut,V. Asher. Chemotherapy improves survival rate in Stage 1 ovarian cancers. European Journal of Gynaecological Oncology. 2018. 39(1);49-52.

References

[1] UK Cancer Research, 2015. Available at: http://www.cancerresearchuk. org/health-professional/cancer-statistics/statistics-bycancer-type/ovarian-cancer/incidence - heading-Zero.

[2] NICE Clinical Guideline 122: The recognition and initial management of ovarian cancer. 2011: Cardiff (UK). Available at:

https://www.nice.org.uk/Guidance/CG122

[3] Winter-Roach B.A., Kitchener H.C., Lawrie T.A.: Adjuvant (postsurgery) chemotherapy for early stage epithelial ovarian cancer. Cochrane Database Syst. Rev., 2012, 3, CD004706.

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[5] Trimbos J.B., Parmar M., Vergote I., Guthrie D., Bolis G., Colombo N., et al.: “International Collaborative Ovarian Neoplasm trial 1 and Adjuvant ChemoTherapy In Ovarian Neoplasm trial: two parallel randomized phase III trials of adjuvant chemotherapy in patients with early-stage ovarian carcinoma”. J. Natl. Cancer. Inst., 2003, 95, 105.

[6] Collinson F., Qian W., Fossati R., Lissoni A., Williams C., Parmar M., et al.: “Optimal treatment of early-stage ovarian cancer”. Ann. Oncol., 2014, 25, 1165.

[7] Ovarian Cancer National Alliance: “Risk factors”. 2015. Available at: http://www.ovariancancer.org/about/risk-factors/

[8] Vergote, I., De Brabanter J., Fyles A., Bertelsen K., Einhorn N., Sevelda P. “Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma”. Lancet, 2001, 357, 176.

[9] Winter-Roach B.A., Kitchener H. C., Lawrie T.A.: “Adjuvant (post-postsurgery) chemotherapy for early stage epithelial ovarian cancer”. Cochrane Database Syst. Rev., 2015, 12, CD004706.

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