Cervical dysplasia during pregnancy - Effects on oncological and psychological outcome: a case control study

Pregnant patients with cervical intraepithelial neoplasia Grade 3 (CIN 3) are monitored in 8- to 12-weekly intervals unless invasive carcinoma is suspected. The aim of this case-control study was to evaluate differences in regression and healing rates as well as posttraumatic stress levels. Materials and Methods: Treatment and outcome were analysed retrospectively. Stress levels were measured using the standardized German version of the Impact of Event Scale-Revised (IES-R) questionnaire. Results: Spontaneous regression was seen in 26.9% of cases. Progression to invasive cancer was not detected. 88.2% of all pregnant and 88.3% of all non-pregnant women were regarded as healed. Stress level was not significantly higher in non-pregnant patients. Conclusion: Cervical dysplasia in pregnancy shows high spontaneous regression potential. Regression is associated with long-time healing of dysplasia. An observant approach in patients with CIN3 during pregnancy does not cause higher stress levels.

HSIL; CIN; Cervical dysplasia; Pregnancy; Post-traumatic stress levels.

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