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Metastatic ovarian cancer and gastrointestinal stromal tumor on the grounds of neurofibromatosis. A case report and review of the literature

  • G.M. Makris1,2,*,
  • A. Makrysopoulou2
  • M.J. Battista3
  • C. Chrelias2

1Department of Obstetrics and Gynecology, Rea Maternity Hospital, Athens, Greece

2Gynecological Oncology Unit, Third Department of Obstetrics and Gynecology, General University Hospital "Attikon", University of Athens, Athens, Greece

3Department of Gynecology and Obstetrics, University Hospital Mainz, Mainz, Germany

DOI: 10.12892/ejgo3803.2017 Vol.38,Issue 5,October 2017 pp.790-792

Published: 10 October 2017

*Corresponding Author(s): G.M. Makris E-mail: makrismg@hotmail.com

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Abstract

Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous syndrome. NF1 patients are at increased risk for both benign and malignant tumors. The authors present the case of a female patient with a medical history of NF1, with an impressive succession of tumors, namely metastatic ovarian cancer and, 20 years later, a gastrointestinal stromal tumor (GIST) of the jejunum. The metastatic ovarian Mullerian adenosarcoma was successfully treated with total abdominal hysterectomy with bilateral salpingo-oophorectomy, radiotherapy, chemotherapy, as well as Gamma Knife radiosurgery of the metastasis in the thalamus. The jejunal GIST was surgically removed. The exploration of molecular pathways that underlie the association between NF1, GISTs, and ovarian cancer may provide valuable insight into the pathogenesis of such cases and assessment of targeted therapies.

Keywords

Neurofibromatosis type 1; Ovarian cancer; Gastrointestinal stromal tumor; Metastasis.

Cite and Share

G.m. Makris, A. Makrysopoulou, M.j. Battista, C. Chrelias. Metastatic ovarian cancer and gastrointestinal stromal tumor on the grounds of neurofibromatosis. A case report and review of the literature. European Journal of Gynaecological Oncology. 2017; 38(5): 790-792. doi: 10.12892/ejgo3803.2017

URL:

https://www.ejgo.net/articles/10.12892/ejgo3803.2017

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