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Asymptomatic ovarian hemangioma in a postmenopausal patient with elevated estrogen
1Department of Gynecology, First Affiliated Hospital of China Medical University, Shenyang
2Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang (China)
*Corresponding Author(s): H. Xue E-mail: xuehui89@hotmail.com
Ovarian hemangiomas are rare. Here, the authors report an asymptomatic ovarian hemangioma in a postmenopausal patient. Ultrasound revealed a left ovarian cyst measuring 2.06×1.74×2.11 cm in a 57-year-old postmenopausal female. On preoperative examination, estrogen and carbohydrate antigen 72-4 (CA72-4) were 131 pmol/L and 7.88 U/mL, respectively. The results of intraoperative frozen section examination and final histopathology were indicative of an ovarian hemangioma. This rare case of asymptomatic ovarian hemangioma with elevated estrogen might demonstrate a possible relationship between estrogen levels and ovarian hemangioma.
Ovarian hemangioma; Estrogen; CA72-4; Asymptomatic.
H. Xue,X.Y. Lin. Asymptomatic ovarian hemangioma in a postmenopausal patient with elevated estrogen. European Journal of Gynaecological Oncology. 2018. 39(5);810-812.
[1] Cormio G., Loverro G., Iacobellis M., Mei L., Selvaggi L.: “Hemangioma of the ovary. A case report”. J. Reprod. Med., 1998, 43, 459.
[2] Huang R.S., Covinsky M., Zhang S.: “Bilateral ovarian capillary hemangioma with stromal luteinization and hyperandrogenism”. Ann. Clin. Lab. Sci., 2013, 43, 457.
[3] Yamawaki T., Hirai Y., Takeshima N., Hasumi K.: “Ovarian hemangioma associated with concomitant stromal luteinization and ascites”. Gynecol. Oncol., 1996, 61, 438.
[4] Erdemoglu E., Kamaci M., Ozen S., Sahin H., Kolusari A.: “Ovarian hemangioma with elevated CA-125 and ascites mimicking ovarian cancer”. Eur. J. Gyneacol. Oncol., 2006, 27, 195.
[5] Itoh H., Wada T., Michikata K., Sato Y., Seguchi T., Akiyama Y., et al.: “Ovarian teratoma showing a predominant hemangiomatous element with stromal luteinization: report of a case and review of the literature”. Pathol. Int., 2004, 54, 279.
[6] Prus D., Rosenberg A.E., Blumenfeld A., Udassin R., Ne’eman Z., Young R.H., et al.: “Infantile hemangioendothelioma of the ovary: A monodermal teratoma or a neoplasm of ovarian somatic cells?” Am. J. Surg. Pathol., 1997, 21, 1231.
[7] Comunoglu C., Atasoy L., Baykal C.: “Ovarian hemangioma occurring synchronously with contralateral mature cystic teratoma in an 81-year-old patient”. Ups. J. Med. Sci., 2010, 115, 297.
[8] Savargaonkar P., Wells S., Graham I., Buckley C.: “Ovarian haemangiomas and stromal luteinization”. Histopathology, 1994, 25, 185.
[9] Carder P., Gouldesbrough D.: “Ovarian haemangiomas and stromal luteinization”. Histopathology, 1995, 26, 585.
[10] Miliaras D., Papaemmanouil S., Blatzas G.: “Ovarian capillary hemangioma and stromal luteinization: a case study with hormonal receptor evaluation”. Eur. J. Gynaecol. Oncol., 2001, 22, 369.
[11] Gücer F., Ozyilmaz F., Balkanli-Kaplan P., Mülayim N., Aydin O.: “Ovarian hemangioma presenting with hyperandrogenism and endometrial cancer: a case report”. Gynecol. Oncol., 2004, 94, 821.
[12] Anand M.S., Shetty S., Mysorekar V.V., Kumar R.V.: “Ovarian hemangioma with stromal luteinization and HCG-producing mononucleate and multinucleate cells of uncertain histogenesis: a rare co-existence with therapeutic dilemma”. Indian J. Pathol. Microbiol., 2012, 55, 509.
[13] Nezhat F., Slomovitz B.M., Saiz A.D., Cohen C.J.: “Ovarian mucinous cystadenocarcinoma with virilization”. Gynecol. Oncol., 2002, 84, 468.
[14] Schoolmeester J.K., Greipp P.T., Keeney G.L., Soslow R.A.: “Ovarian Hemangiomas Do Not Harbor EWSR1 Rearrangements: Clinicopathologic Characterization of 10 Cases”. Int. J. Gynecol. Pathol., 2015, 34, 437.
[15] Sun Z.Y., Yang L., Yi C.G., Zhao H., Han D.L., Yang T., et al.: “Possibilities and potential roles of estrogen in the pathogenesis of proliferation hemangiomas formation”. Med. Hypotheses, 2008, 71, 286.
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