Article Data

  • Views 516
  • Dowloads 115

Case Reports

Open Access

Uterine leiomyosarcoma with skeletal muscle metastasis

  • Ala’ U’wais1
  • Kuan-Gen Huang2,*,
  • Tsung-Hsun Tsa3
  • Yu-Jen Liu4

1Department of Obstetrics and Gynecology, Mutah University, Karak (Jordan)

2Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine,Kweishan, Taoyuan

3Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine,Kweishan, Taoyuan

4Department of Pathology, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, Kweishan, Taoyuan (Taiwan)

DOI: 10.12892/ejgo3855.2018 Vol.39,Issue 2,April 2018 pp.307-309

Published: 10 April 2018

*Corresponding Author(s): Kuan-Gen Huang E-mail: kghuang@ms57.hinet.net

Abstract

Background: Leiomyosarcoma of the uterus is a rare tumor; hence there is lack of evidence on the tumor behavior in terms of prognostic factor for recurrence and its metastatic pattern. Practitioners usually find difficulty in choosing the best management options in treating rare diseases. Case Report: A case of uterine leiomyosarcoma underwent staging laparoscopy and adjuvant chemotherapy. First recurrence was discovered as a single lung nodule after two years follow up, so the patient underwent a metastatectomy. Second recurrence was isolated right biceps muscle metastasis which was removed and followed by chemo-radiotherapy. Patient died one year following the second recurrence. Conclusion: There are no specific pathological findings or independent factors which can predict the metastatic pattern or the site of recurrence. Surgical resection appears to be the best option in management of leiomysarcoma metastasis if feasible. Evidence supports the roll of chemotherapy in non-operable recurrence.

Keywords

Leiomyosarcoma; Metastasis; Recurrence site.

Cite and Share

Ala’ U’wais,Kuan-Gen Huang,Tsung-Hsun Tsa,Yu-Jen Liu. Uterine leiomyosarcoma with skeletal muscle metastasis. European Journal of Gynaecological Oncology. 2018. 39(2);307-309.

References

[1] McMeekin D.S.: “Clinical gynecologic oncology”. 8th ed. In: Sarcoma of the uterus. Philadelphia, PA: Elsevier Saunders, 2012, 175.

[2] Bartosch C., Afonso M., Pires-Luís A.S., Galaghar A., Guimarães M., Antunes L., Lopes JM.: “Distant Metastases in Uterine Leiomyosarcomas: The Wide Variety of Body Sites and Time Intervals to Metastatic Relapse”. Int J Gynecol Pathol., 2016 Mar 24. [Epub ahead of print]

[3] Demicco E.G., Boland G.M., Brewer Savannah K.J., Lusby K., Young E.D., Ingram D.Y., et al.: “Progressive loss of myogenic differentiation in leiomyosarcoma has prognostic value”. Histopathology, 2015, 66, 627.

[4] Kapp D.S., Shin J.Y., Chan J.K.: “Prognostic factors and survival in 1396 patients with uterine leiomyosarcomas: emphasis on impact of lymphadenectomy and oophorectomy”. Cancer, 2008, 112, 820.

[5] Lusby K., Savannah K.B., Demicco E.G., Zhang Y., Ghadimi M.P., Young E.D., et al.: “Uterine leiomyosarcoma management, outcome, and associated molecular biomarkers: a single institution’s experience”. Ann. Surg. Oncol., 2013, 20, 2364.

[6] Surov A., Köhler J., Wienke A., Gufler H., Bach A.G., Schramm D., et al.: “Muscle metastases: comparison of features in different primary tumours”. Cancer Imaging, 2014, 14, 21.

[7] Amant F., Lorusso D., Mustea A., Duffaud F., Pautier P.: “Management strategies in advanced uterine leiomyosarcoma: focus on trabectedin”. Sarcoma, 2015, 2015, 704124.

[8] Sarcoma Meta-analysis Collaboration (SMAC): “Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults. Sarcoma Meta-analysis Collaboration (SMAC)”. Cochrane Database Syst Rev., 2000, 4, CD001419.

[9] Woll P.J., Reichardt P., Le Cesne A., Bonvalot S., Azzarelli A., Hoekstra H.J., et al.: “Adjuvant chemother- apy with doxorubicin, ifosfamide, and lenograstim for resected so -tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial”. Lancet Oncol., 2012, 13, 1045.

[10] Surov A., Hainz M., Holzhausen H.J., Arnold D., Katzer M., Schmidt J., et al.: “Skeletal muscle metastases: primary tumours, prevalence, and radiological features”. Eur. Radiol., 2010, 20, 649.

[11] Hensley M.L., Blessing J.A., Mannel R., Rose P.G.: “Fixed-dose rate gemcitabine plus docetaxel as second-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase II study”. Gynecol. Oncol., 2008, 109, 323.

[12] Hensley M.L., Blessing J.A., Mannel R., Rose P.G.: “Fixed- dose rate gemcitabine plus docetaxel as rst-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase II trial”. Gynecol. Oncol., 2008, 109, 329.

[13] Hensley M.L., Maki R., Venkatraman E., Geller G., Lovegren M., Aghajanian C., et al.: “Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial”. J. Clin. Oncol., 2002, 20, 2824.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top