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Ovarian borderline clear cell adenofibroma in a 42-year-old woman: a case report and a literature review


  • Qiongxian Long1,2
  • Jiyan Liu1,*,
  • Yong Peng3
  • Zhirong Tang2
  • Cailiang Wu2

1Department of Abdominal Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China

2Department of Pathology, Nanchong Central Hospital,North Sichuan Medical University, Nanchong, China

3Department of Gynaecology and Obstetrics, Nanchong Central Hospital, North Sichuan Medical University, Nanchong, China

DOI: 10.12892/ejgo3943.2018 Vol.39,Issue 6,December 2018 pp.1004-1006

Published: 15 December 2018

*Corresponding Author(s): Jiyan Liu E-mail: liujiyan1972@163.com

Abstract

Borderline clear cell adenofibroma of the ovary is rather rare since most clear cell tumors are carcinomas. Most patients with ovarian borderline clear cell adenofibroma are older than 50, with only a few cases of women younger than 50. Here, the authors report a 42-year-old woman with ovarian borderline clear cell adenofibroma. The surgical specimen was used for a pathological examination and immunohistochemistry. Macroscopically, the mass in the right ovary was relatively large, measuring 12×10×8 cm. Microscopically, the tumor showed the characteristic histologic features of borderline clear cell adenofibroma such as variation in size and shape of glands, cell atypia, and absence of stromal invasion. The patient had an uneventful recovery from the operation without any complications, recurrence, or metastasis during the two-year follow-up period. The prognosis of borderline clear cell adenofibroma is excellent, but the patient required long-term follow-up.

Keywords

Carcinoma; Borderline clear cell adenofibroma; Ovary.

Cite and Share

Qiongxian Long,Jiyan Liu,Yong Peng,Zhirong Tang,Cailiang Wu. Ovarian borderline clear cell adenofibroma in a 42-year-old woman: a case report and a literature review. European Journal of Gynaecological Oncology. 2018. 39(6);1004-1006.

References

[1] Bell D.A., Scully R.E.: “Benign and borderline clear cell adenofibromas of the ovary”. Cancer, 1985, 56, 2922.

[2] Roth L.M., Langley F.A., Fox H., Wheeler J.E., Czernobilsky B.: “Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma”. Cancer, 1984, 53, 1156.

[3] Zhao C., Wu L.S., Barner R.: “Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development”. J. Cancer, 2011, 2, 94.

[4] Yamamoto S., Tsuda H., Yoshikawa T., Kudoh K., Kita T., Furuya K., et al.: “Clear cell adenocarcinoma associated with clear cell adenofibromatous components: a subgroup of ovarian clear cell adenocarcinoma with distinct clinicopathologic characteristics”. Am. J. Surg. Pathol., 2007, 31, 999.

[5] Yamamoto S, Tsuda H, Takano M et al. Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. J Pathol. 2008; 216:103-10.

[6] Yamamoto S., Tsuda H., Takano M., Hase K., Tamai S., Matsubara O.: “Expression of platelet-derived growth factors and their receptors in ovarian cell carcinoma and its putative precursors”. Mod. Pathol., 2008, 21, 115.

[7] Tavassoli F.A., Devilee P. (eds). World Health Organization classification of tumours. In: Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003, 218.

[8] Zhao C., Wu L.S., Barner R.: “Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or ade nofibromatous components support two related pathways oftumor development”. J. Cancer, 2011, 2, 94.

[9] Yamamoto S., Tsuda H., Miyai K., Takano M., Tamai S., Matsubara O.: “Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways”. Virchows Arch., 2009, 455, 413.

[10] Yamamoto S., Tsuda H., Takano M., Hase K., Tamai S., Matsubara O.: “Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clearcell carcinogenic pathway”. J. Pathol., 2008, 216, 103.

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