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Original Research

Open Access

A retrospective study of clinicopathological characteristics, treatment, and outcomes of Chinese uterine and ovarian carcinosarcoma patients

  • Jun Zhu1,2
  • Hao Wen1,2
  • Rui Bi2
  • Xiaohua Wu1,2,*,

11Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai,China

2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai,China

3Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai ,China

DOI: 10.12892/ejgo4043.2018 Vol.39,Issue 3,June 2018 pp.448-453

Published: 10 June 2018

*Corresponding Author(s): Xiaohua Wu E-mail: docwuxh@163.com

Abstract

This study aimed to determine the clinicopathological and prognostic factors, and to assess the impact of cytoreduction to complete gross resection in Chinese uterine and ovarian carcinosarcoma patients. Materials and Methods: The authors reviewed 86 consecutive patients treated for uterine (n=60) or ovarian (n=26) carcinosarcomas between February 2006 and August 2013 at Fudan University Shanghai Cancer Center. Results: The median follow-up time was 24.0 months [interquartile range (IQR): 12.4 to 48.7]. The median age was 59 years (IQR: 53 to 66). The three- and five-year overall survival rates were 60.1% and 42.8%, respectively. Extent of tumor dissemination, mesenchymal component, and adjuvant therapy were predictive of overall survival. Among advanced carcinosarcoma patients, complete gross resection (R 0 ) had a three-year overall survival rate of 52.5%, vs. 38.9% and 20.8% in patients with gross residual disease ≤ 1cm and > 1cm (p = 0.004). On multivariate analysis, only heterologous mesenchymal component (HR=4.8; 95% CI, 1.4-16.7; p = 0.015) and gross residual disease (HR=2.6, 95% CI: 1.2-5.9; p = 0.019) were predictors of increased mortality. Conclusions: Heterologous tumor and incomplete gross resection were significantly predictive of a poor overall survival in carcinosarcoma patients. We recommend cytoreduction to R 0 for upfront treatment in CS patients.

Keywords

Ovarian carcinosarcoma; uterine carcinosarcoma; prognostic factors; cytoreduction

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Jun Zhu,Hao Wen,Rui Bi,Xiaohua Wu. A retrospective study of clinicopathological characteristics, treatment, and outcomes of Chinese uterine and ovarian carcinosarcoma patients. European Journal of Gynaecological Oncology. 2018. 39(3);448-453.

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