An immunological explanation behind the acantholytic dermatosis of vulvocrural area

The acantholytic dermatosis of the vulvocrural area (ADVA) is a rare skin disorder of unknown etiology, described for the first time by Chorzelski et al. in 1984. It is characterized by solitary or multiple skin-coloured to white, smooth papules or plaques, involving the genitocrural region, in particular the vulva. Here, the authors refer a case of ADVA in an 80-year-old female patient affected by recurrent endometrial carcinoma. The immunohistochemical investigation demonstrated the exclusive presence of G immunoglobulins inside the skin lesions, so indicating a paraneoplastic immunological action. The findings shed light on the etiopathogenetic mechanisms at the basis of this still scantly known nosological entity.

Acantholytic dermatosis of the vulvocrural area; Endometrioid carcinoma; Paraneoplastic syndrome; Immunoglobulins; Immunohistochemistry; Histology.

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