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A case report of metastatic bilateral ovarian cancer due to non-small cell lung cancer with ALK gene rearrangement

  • Zhitong Liu1
  • Bo Liu2,*,
  • Changzhong Li1

1Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China

2Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan, China

DOI: 10.12892/ejgo4203.2019 Vol.40,Issue 1,February 2019 pp.151-153

Accepted: 09 March 2017

Published: 10 February 2019

*Corresponding Author(s): Bo Liu E-mail: lzt236834@163.com

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Abstract

Ovarian cancer patients are becoming more and more frequent; a part of them are metastatic ovarian cancer patients, which mostly come from colon, stomach, appendix, and pancreas, rarely come from lung. The authors report a case of metastatic bilateral ovarian cancer due to non-small cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK) gene rearrangement. This female patient was diagnosed with adenocarcinoma of lung (cT3N2M1 Stage IV) and received chemotherapy and targeted drug therapy. She was diagnosed with metastatic ovarian cancer from lung by CT, and puncture biopsy and pathologic examination after surgery. Cancer gene detection confirmed ALK gene rearrangement. ALK gene rearrangement may increase the rate of metastasis of lung cancer, and as the target spot of tumor targeted therapy, it may provide an important treatment method for primary tumor and metastasis.

Keywords

Metastatic bilateral ovarian cancer; Non-small cell lung cancer (NSCLC); Adenocarcinoma of lung; ALK gene rearrange- ment; Crizotinib

Cite and Share

Zhitong Liu,Bo Liu,Changzhong Li. A case report of metastatic bilateral ovarian cancer due to non-small cell lung cancer with ALK gene rearrangement. European Journal of Gynaecological Oncology. 2019. 40(1);151-153.

URL:

https://www.ejgo.net/articles/10.12892/ejgo4203.2019

References

[1] Irving J.A., Young R.H.: “Lung carcinoma metastatic to the ovary: a clinic pathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis”. Am. J. Surg. Pathol., 2005, 29, 997.

[2] Soda M., Choi Y.L., Enomoto M., Takada S., Yamashita Y., Ishikawa S., et al.: “Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer”. Nature, 2007, 448, 561.

[3] Solomon B., Varella-Garcia M., Camidge D.R.: “ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung.cancer”. J. Thorac. Oncol., 2009, 4, 1450.

[4] Lee K.A., Lee J.S., Min J.K., Kim H.J., Kim W.S., Lee K.Y.1.: “Bilateral Ovarian Metastases from ALK Rearranged Non-Small Cell Lung Cancer”. Tuberc. Respir. Dis. (Seoul), 2014, 77, 258.

[5] Fujiwara A., Higashiyama M., Kanou T., Tokunaga T., Okami J., Kodama K., et al.: “Bilateral ovarian metastasis of non-small cell lung cancer with ALK rearrangement”. Lung Cancer, 2014, 83, 302.

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