Ovarian Leydig cell tumour in a postmenopausal woman with alopecia

Hyperandrogenism in females usually results from ovarian and/or adrenal pathology. A rapid progression of clinical manifestations, such as hirsutism, male-pattern hair loss, and clitoromegaly can strongly suggest androgen-secreting neoplasm. The authors describe a case of a postmenopausal 64-year-old woman, presented with advanced androgenic alopecia and progressive hirsutism arising over three years. The patient suffered from many internal disorders. Hormonal tests revealed high total levels of testosterone and estradiol. A solid tumour of the right ovary measuring 15×13×16 mm with strong enhancement was observed in pelvic dynamic MRI. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy were performed. Histology revealed a 2.5-cm right ovary containing a 1.8-cm sized beige-yellow tumour, identified as Leydig cell ovarian tumour with positive result of inhibin staining. Postoperatively, testosterone level returned to normal with a gradual regression of clinical symptoms.

Hyperandrogenism; Adrenal glands; Hirsutism; Ovarian Leydig cell tumour

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