Hereditary endometrial cancer: a case report

Introduction: Endometrial cancer (EC) is one of the commonest malignancies of the female reproductive tract. In recent years, the heredity and familial clustering of EC has been described by researchers, but few cases are reported from China. Cases Report: A 50- years-old Chinese women presented with irregular vagina bleeding for more than 20 days.The clinical impression was EC and she was treated by surgery and chemotherapy. Four years later, her mother and two sisters were also diagnosed with EC in the same hospital. The authors therefore summarized the case profiles of this family to learn more about familial hereditary EC. Conclusion: The authors present four cases of hereditary EC from one family pedigree. For individuals who have a family history of EC, it is necessary to promote molecular genetic test and gynecological screening for early detection and prevention.

Endometrial cancer (EC); Heredity and familial clustering; Genetic testing.

[1] Purdie D.M., Green A.C.: “Epidemiology of endometrial cancer”. Best Pract. Res. Clin. Obstet. Gynaecol., 2001, 15, 341.

[2] Gruber S.B., Thompson W.D.: “A population-based study of endometrial cancer and familial risk in younger women”. Cancer Epidemiol. Biomarkers Prev., 1996, 5, 411.

[3] Liu H., Zhao Y.: “Research Progress of Hereditary Endometrial Carcinoma. Maternal and Child Health Care of China. 2015; 30: 972-4.

[4] Kuliev A, Verlinsky Y. The role of preimplantation genetic diagnosis in women of advanced reproductive age”. Curr. Opin. Obstet. Gynecol., 2003, 15, 233.

[5] Rouprêt M., Yates D.R., Comperat E., Cussenot O.:” Upper urinary tract urothelial cell carcinomas and other urological malignancies involved in the hereditary nonpolyposis colorectal cancer (Lynch syndrome) tumor spectrum”. Eur. Urol., 2008, 54, 1226.

[6] Parc Y.R., Halling K.C., Burgart L.J., McDonnell S.K., Schaid D.J., Thibodeau S.N., et al.: “Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology”. Int. J. Cancer, 2000, 86, 60.

[7] Lynch H.T., Smyrk T.C., Watson P., Lanspa S.J., Lynch J.F., Lynch P.M., et al.: “Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review”. Gastroenterology, 1993, 104, 1535.

[8] Kwon J.S., Sun C.C., Peterson S.K., White K.G., Daniels M.S., Boyd-Rogers S.G., et al.: “Cost-effectiveness analysis of prevention strategies for gynecologic cancers in Lynch syndrome”. Cancer, 2008, 113, 326.