Article Data

  • Views 2076
  • Dowloads 121

Case Reports

Open Access

A case of a virilising adult granulosa cell tumour

  • R.A. Sharma1,*,
  • C. Spyroulis1
  • M. Nawar1

1Department of Obstetrics and Gynaecology, Northwick Park Hospital, London North West University Healthcare NHS Trust, Harrow, United Kingdom

2Department of Obstetrics and Gynaecology, Crosshouse University Hospital, Ayshire and Arran NHS Health Board, Crosshouse, United Kingdom

DOI: 10.12892/ejgo4312.2019 Vol.40,Issue 1,February 2019 pp.140-142

Accepted: 01 August 2017

Published: 10 February 2019

*Corresponding Author(s): R.A. Sharma E-mail: rowenasharma@yahoo.co.uk

Abstract

Ovarian granulosa cell tumour (GCT) is recognized by two types: adult and juvenile. The diagnosis, treatment, and follow-up of a case of virilising adult GCT is reported.

Keywords

Ovarian granulosa tumour; Virilisation

Cite and Share

R.A. Sharma,C. Spyroulis,M. Nawar. A case of a virilising adult granulosa cell tumour. European Journal of Gynaecological Oncology. 2019. 40(1);140-142.

References

[1] Scully R.E., Young R.H., Clement P.B.: “Tumours of the ovary, maldeveloped gonads, fallopian tube and broad ligament.” In: Rosai J., Sobin L.H. (eds). Atlas of tumour Pathology. Washington, D.C: Armed Forces Institute of Pathology, 1996, 169.

[2] Nakashima N., Young R.H., Scully R.E.: “Androgenic granulosa cell tumours of the ovary. A Clinicopathologic analysis of 17 cases and review of the literature”. Arch. Pathol. Lab. Med., 1984, 108, 786.

[3] Young R.H., Dickersin G.R., Scully R.E.: “Juvenile granulosa cell tumour of the ovary: a clinicopathological analysis of 125 cases”. Am. J. Surg. Pathol., 1984, 8, 575.

[4] Lack E.E., Perez-Atayde A.R., Murthy S.K., Goldstein D.P., Crigler J.F., Vawter G.F.: “Granulosa Theca cell tumours in Premenarchal Girls: A Clinical and pathological study of ten cases”. Cancer, 1981, 48, 1846.

[5] Young R.H., Scully R.E.: “Endocrine tumours of the ovary”. Curr. Top. Pathol., 1992, 85, 114-164.

[6] Dhont M., Duvivier P., Vanderkerckhove D.: “A solid virilising granulosa cell tumour”. Eur. J. Obstet. Gynecol. Reprod. Biol., 1985, 20, 253-256.

[7] Kabaka C., Karateke A., Gurbuz A., Cesur S.: “Androgenic adult granulosa cell tumour in a teenager: a case report and review of the literature”. Int. J. Gynecol. Cancer, 2006, 16, 368.

[8] Nasu K., Fukuda J., Yoshimatsu J., Takai N., Kashima K., Narahara H.: “Granulosa cell tumour associated with secondary amenorrhoea and serum luteinising hormone elevation”. Int. J. Clin. Oncol., 2007, 12, 228.

[9] Moon Y.S., Tsang D.K., Simpson C., Armstrong D.T.: “17b-estradiol biosynthesis in cultured granulosa and theca cells of human ovarian follicles: stimulation by follicle-stimulating hormone”. J. Clin. Endocrinol. Metab., 1978, 47, 263.

[10] McNatty K.P., Makris A., DeGrazia C., Osathanondh R., Ryan K.J.: “The production of progesterone, androgens and oestrogens by granulosa cells, thecal tissue and stromal tissue from human ovaries in vitro”. J. Clin. Endocrinol. Metab., 1979, 49, 687.

[11] Valk T.W., Corley K.P., Kelch R.P., Marshall J.C.: “Pulsatile gonadotrophin-releasing hormone in gonadotrophin-deficient and normal men: suppression of follicle-stimulating hormone responses by testosterone”. J. Clin. Endocrinol. Metab.,1981, 53, 184.

[12] Nomelini R.S., Micheletti A.M.R., Adad S.J., Murta E.F.C.: “Androgenic juvenile granulosa cell tumour of the ovary with cystic presentation: a case report”. Eur. J. Gynecol. Oncol., 2007, 28, 236.

[13] Kalfa N., Meduri G., Philibert P., Patte C., Boizet-Bonhoure B., Thibaut E., et al.: “Unusual virilisation in girls with Juvenile Granulosa cell tumours of the ovary is related to intratumoral aromatase deficiency”. Horm. Res. Paediatr., 2010, 74, 83.

[14] Wilson J.S., Young B.K., Katz M., Kammerman S., Epstein J., Bigelow B.: “A gonadotrophin-responsive virilising granulosa tumour”. Diagn. Gynecol. Obstet., 1980, 2 (no. 4), 275-281.

[15] Castro C.V., Malpica A., Hearne R.H., Silva E.G.: “Androgenic adult granulosa cell tumour in a 13-yr old pre-pubertal patient: a case report and review of the literature”. Int. J. Gynecol. Pathol., 2000, 9, 266.

[16] Ohel G., Kaneti H., Schenker J.G.: “Granulosa cell tumours in Israel: a study of 172 cases”. Gynecol. Oncol.,1983, 15, 278.

[17] Calaminus G., Wessalowski R., Harms D., Gobel U.: “Juvenile granulosa cell tumours of the ovary in children and adolescents: results form 33 patients registered in a prospective cooperative study”. Gynecol. Oncol., 1997, 65, 447.

[18] Aboud E.: “Adult granulosa cell tumours of the ovary”. Eur. J. Gynaecol. Oncol.,1997, 18, 520-522.

[19] Fox H., Buckley C.: “Pathology of malignant gonadal stromal tumours of ovary”. In: Coppleson M., (ed). Gynaecologic Oncology. Edinburgh: Churchill Livingstone,1992, 59, 947.

[20] Petraglia F., Luisi F., Pautier P., Sabourin J.C., Rey R., Lhomme C., Bidart J.M.: “Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumours”. J. Clin. Endocrinol. Metab., 1998, 82, 1029.

Submission Turnaround Time

Top