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Original Research

Open Access

High immunoexpression of progesterone-induced blocking factor (PIBF) in endometrial cancer

  • E. Sahin1
  • Y. Madendag1
  • M.E. Sahin3
  • I.C. Madendag1
  • A.T. Tayyar4,*,
  • F. Senel2
  • H. Karaman2
  • G. Acmaz1

1Department of Obstetrics and Gynecology, Health Sciences University Kayseri Education and Research Hospital, Kayseri, Turkey

2Department of Pathology, Health Sciences University Kayseri Education and Research Hospital, Kayseri, Turkey

3Department of Obstetrics and Gynecology, Erciyes University Faculty of Medicine, Kayseri, Turkey

4Department of Obstetrics and Gynecology, Health Sciences University Zeynep Kamil Maternity and Childrens Training and Research Hospital, Istanbul, Turkey

DOI: 10.12892/ejgo4338.2019 Vol.40,Issue 1,February 2019 pp.80-83

Accepted: 19 July 2017

Published: 10 February 2019

*Corresponding Author(s): A.T. Tayyar E-mail: drahtertayyar@yahoo.com

Abstract

Purpose of Investigation: This study aims to investigate PIBF expression levels in normal, hyperplastic, and endometrioid adenocarcinoma paraffin blocks. The purpose of this study is to determine the PIBF expression levels in endometrial cancer cells. Materials and Methods: A total of 90 patients were investigated. Thirty of those were diagnosed as having normal endometrial tissue, 30 had endometrial hyperplasia, and 30 had endometrioid adenocarcinoma. The expression of PIBF was assessed using immunohistochemically using paraffin-embedded tissue blocks. Results: Tissue sections were compared based on immunostaining with PIBF. The authors detected higher stromal PIBF expression in the endometrioid adenocarcinoma group as compared to the endometrial hyperplasia and normal endometrium groups (p < 0.001). The glandular PIBF expression did not differ among the groups (p > 0.05). Conclusions: Endometrial cancer cells have higher levels of expression of PIBF protein than normal endometrial tissue and endometrial hyperplasia tissue based on immunohistochemistry staining. PIBF immunostaining may be helpful in preoperatively differentiating between atypical endometrial hyperplasia (AEH) and endometrioid adenocarcinoma (EC) in suspicious cases.

Keywords

Progesterone-induced blocking factor; PIBF, Endometrioid adenocarcinoma; Immunostaining

Cite and Share

E. Sahin,Y. Madendag,M.E. Sahin,I.C. Madendag,A.T. Tayyar,F. Senel,H. Karaman,G. Acmaz. High immunoexpression of progesterone-induced blocking factor (PIBF) in endometrial cancer. European Journal of Gynaecological Oncology. 2019. 40(1);80-83.

References

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