Fertility preservation for a patient with placental site trophoblastic tumor: a case report with literature review

Placental site trophoblastic tumor (PSTT) is a rare trophoblastic tumor with complete hysterectomy as the primary treatment. Here the authors report one case received lesionectomy with fertility preserved under the patient’s desire of reproduction. A 24-year-old woman was admitted because of four-month irregular vaginal bleeding following a natural delivery of a full-term baby nine months ago. As the tumor was confined to the uterus, a cross-wall wedge cut was made to remove the lesion together with 1 cm of surrounding healthy tissues. Immunohistochemistry of biopsy accorded with PSTT. No recurrence was evident during 15-month postoperative follow-up. Referring to literature, the authors recommend that patients with reproduction requirement with PSTT restricted to uterus could undergo a lesionectomy to retain fertility. Chemotherapy could be supplemental when high-risk factors exist.

Placental site trophoblastic tumor; Fertility preservation

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