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Fertility-sparing management for bulky cervical cancer with systemic chemotherapy and conization: a case report and review of the literature

  • Lili Qian1,†,#
  • Zhen Shen1,†,#
  • Dabao Wu1
  • Dabao Wu1,†
  • Ying Zhou1,*,

1Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China

DOI: 10.12892/ejgo4455.2019 Vol.40,Issue 4,August 2019 pp.684-687

Accepted: 26 October 2017

Published: 10 August 2019

*Corresponding Author(s): Ying Zhou E-mail: caddie1234@gmail.com

† These authors contributed equally.

About author: #Co-first authors.

Abstract

Herein the authors report the case of a patient with FIGO Stage Ib2 cervical cancer, experienced a complete response treated by neoadjuvant chemotherapy (NACT) followed by conization. Then she became pregnant and delivered a healthy boy at 38 weeks and exhibited no recurrent disease until July 2017 (82 months after surgery). To the present authors’ knowledge, this is the first report describing this conservative treatment in locally advanced disease.

Keywords

Locally advanced cervical cancer; Neoadjuvant chemotherapy; Pregnancy; Conization

Cite and Share

Lili Qian,Zhen Shen,Dabao Wu,Dabao Wu,Ying Zhou. Fertility-sparing management for bulky cervical cancer with systemic chemotherapy and conization: a case report and review of the literature. European Journal of Gynaecological Oncology. 2019. 40(4);684-687.

References

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[2] Saadi J.M., Perrotta M., Orti R., Salvo G., Giavedoni M.E., Gogorza S., et al.: “Laparoscopic radical trachelectomy: technique, feasibility, and outcomes”. JSLS, 2015, 19, e2013.

[3] Lee J., Kim T.H., Kim G.E., Keum K.C., Kim Y.B.: “ Neoadjuvant chemotherapy followed by surgery has no therapeutic advantages over concurrent chemoradiotherapy in International Federation of Gynecology and Obstetrics stage IB-IIB cervical cancer”. J. Gynecol. Oncol., 2016, 27:e52.

[4] Marchiole P., Tigaud J.D., Costantini S., Mammoliti S., Buenerd A., Moran E., et al.: “Neoadjuvant chemotherapy and vaginal radical trachelectomy for fertility-sparing treatment in women affected by cervical cancer (FIGO stage IB-IIA1)”. Gynecol. Oncol., 2011, 122, 484.

[5] Palaia I, Musella A, Loprete E, Achilli C, Perniola G, Panici PB.: “Neoadjuvant chemotherapy plus fertility-sparing surgery in locally advanced cervical cancer: case report”. J. Minim. Invasive Gynecol., 2011, 18, 121.

[6] Tsubamoto H., Kanazawa R., Inoue K., Ito Y., Komori S., Maeda H., et al.: “Fertility-sparing management for bulky cervical cancer using neoadjuvant transuterine arterial chemotherapy followed by vaginal trachelectomy”. Int. J. Gynecol. Cancer, 2012, 22, 1057.

[7] Robova H., Halaska M.J., Pluta M., Skapa P., Matecha J., Lisy J., et al.: “Oncological and pregnancy outcomes after high-dose density neoadjuvant chemotherapy and fertility-sparing surgery in cervical cancer”. Gynecol. Oncol., 2014, 135, 213.

[8] Robova H., Rob L., Halaska M.J., Pluta M., Skapa P.: “Review of neoadjuvant chemotherapy and trachelectomy: which cervical cancer patients would be suitable for neoadjuvant chemotherapy followed by fertility-sparing surgery?” Curr. Oncol Rep., 2015, 17, 446.

[9] Feng Y., Cao T., Wang Y., Huang H., Xie Y., Liu J.: “Neoadjuvant chemotherapy followed by conization to spare fertility in cases of locally advanced cervical cancer: A case report and review of the literature”. Mol. Clin Oncol., 2016, 5, 411.

[10] Tsuji N., Butsuhara Y., Yoshikawa H., Terakawa K., Nagano T.: “Pregnancy after neoadjuvant chemotherapy followed by abdominal radical trachelectomy in stage IB2 cervical cancer: A case re- port”. Gynecol. Oncol., 2012, 4, 13.

[11] Shoji T., Takatori E., Furutake Y., Takada A., Nagasawa T., Omi H., et al.: “Phase II clinical study of neoadjuvant chemotherapy with CDDP/CPT-11 regimen in combination with radical hysterectomy for cervical cancer with a bulky mass”. Int. J. Clin. Oncol., 2016, 21, 1120.

[12] Martinelli F., Signorelli M., Bogani G., Ditto A., Chiappa V., Perotto S, et al.: “Is aortic lymphadenectomy indicated in locally advanced cervical cancer after neoadjuvant chemotherapy followed by radical surgery? A retrospective study on 261 women”. Eur. J. Surg. Oncol., 2016, 42, 1512.

[13] Kobayashi Y., Akiyama F., Hasumi K.: “A case of successful pregnancy after treatment of invasive cervical cancer with systemic chemotherapy and conization”. Gynecol. Oncol., 2006, 100, 213.

[14] Vercellino G.F., Piek J.M., Schneider A., Kohler C., Mangler M., Speiser D., et al.: “Laparoscopic lymph node dissection should be performed before fertility preserving treatment of patients with cervical cancer”. Gynecol. Oncol., 2012, 126, 325.

[15] Wang D., Yang J., Shen K., Xiang Y.: “Neoadjuvant chemotherapy followed by fertility-sparing surgery for women with stage IB1 cervical cancer”. J. Gynecol. Oncol., 2013, 24, 287.

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