Article Data

  • Views 224
  • Dowloads 143

Case Reports

Open Access

Postpartum choriocarcinoma: a rare case report and review of literature


  • Na Guo1,2
  • R. Yin1,2
  • Q. Li1,2
  • L. Song1,2
  • D. Wang1,2,*,

1The Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, Sichuan

2Key laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education ,China

DOI: 10.12892/ejgo4537.2019 Vol.40,Issue 3,June 2019 pp.480-483

Published: 10 June 2019

*Corresponding Author(s): D. Wang E-mail: danqingwang@163.com

Abstract

Background: Postpartum choriocarcinoma is a rare complication of pregnancy; early diagnosis is important because this rare condition is potentially curable with appropriate chemotherapy. Case Report: Twenty-nine women with postpartum choriocarcinoma were treated at West China Second University Hospital. The most common symptom among the 29 patients with postpartum choriocarcinoma was irregular vaginal bleeding (27/29), one patient had amenorrhea symptoms (1/29), and one patient with ultrasound showed uterine lesion with no symptom (1/29). Diagnosis was made by the level of serum β-hCG, pelvic ultrasound, and radiological investigation. Treatment with multiagent chemotherapy was successful in all cases. Conclusions: The most common symptom of patients with postpartum choriocarcinoma was genital bleeding, and the overall prognosis may be improved by early diagnosis and an appropriate chemotherapy regimen.

Keywords

Postpartum choriocarcinoma; Early diagnosis; Clinical manifestation; Gestational trophoblast tumor.

Cite and Share

Na Guo,R. Yin,Q. Li,L. Song,D. Wang. Postpartum choriocarcinoma: a rare case report and review of literature. European Journal of Gynaecological Oncology. 2019. 40(3);480-483.

References

[1] Bagshawe K.D., Dent J., Webb J.: “Hydatidiform mole in England and Wales 1973-1983”. Lancet, 1986, 2, 673.

[2] Ma Y., Xiang Y., Wan X.R., Chen Y., Feng F.Z., Lei C.Z., Yang X.Y.: “The prognostic analysis of 123 postpartum choriocarcinoma cases”. Int. J. Gynecol. Cancer, 2008, 18, 1097.

[3] Huang B., Zhang Y.P., Yuan D.F., Yang R., Wang C., Wu R.F1.: “Chorangiocarcinoma: a case report and clinical review”. Int. J. Clin. Exp. Med., 2015, 8, 16798.

[4] Yousefi Z., Mottaghi M., Rezaei A., Ghasemian S.: “Abnormal presentation of choriocarcinoma and literature review”. Iran J. Cancer Prev., 2016, 9, e4389.

[5] Feng F., Xiang Y.: “Surgical management of chemotherapy-resistant gestational trophoblastic neoplasia”. Expert Rev. Anticancer Ther., 2010, 10, 71.

[6] Berkowitz R.S., Goldstein D.P.: “Current advances in the management of gestational trophoblastic disease”. Gynecol. Oncol., 2013 128, 3.

[7] Fatemeh G., Mojgan K.Z.: “Early onset of metastatic gestational trophoblastic disease after full-term pregnancy”. Int. J. Biomed. Sci., 2008, 4, 74.

[8] Riyami N.A., Gowri V., Kakaria A.K., Lakhtakia R.: “A case of postpartum choriocarcinoma: delay in diagnosis and lessons learnt”. The J. Obstet. Gynaecol. India, 2014, 64, 29.

[9] Farley J.H., Heathcock R.B., Branch W., Larsen W., Homas D.: “Treatment of metastatic gestational choriocarcinoma with oral methotrexate in a combat environment”. Obstet. Gynecol., 2005, 105, 1250.

[10] Ma Y., Xiang Y,. Wan X.R., Chen Y., Feng F.Z., Lei C.Z., Yang X.Y.: “The prognostic analysis of 123 postpartum choriocarcinoma cases”. Int. J. Gynecol. Cancer, 2008, 18, 1097.

[11] Powles T., Young A., Sanittt A., Stebbing J., Short D., Bower M., et al.: “The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours”. Br. J. Cancer, 2006, 95, 1145.

[12] Karadeniz T., Topsakal M., Ozkaptan O., Cakir C.: “Bilateral renal choriocarcinoma in a postmenopausal woman”. Korean J. Urol., 2011, 52, 498.

[13] Seckl M.J., Gillmore R., Foskett M., Sebire N.J., Rees H., Newlands E.S.: “Routine terminations of pregnancy should we screen for gestational trophoblastic neoplasia?” Lancet, 2004, 364, 705.

[14] Dobson L.S., Gillespie A.M., Coleman R.E., Hancock B.W.: “The presentation and management of post-partum choriocarcinoma”. Br. J. Cancer, 1999, 79, 1531.

[15] Ryu N., Ogawa M., Matsui H., Usui H., Shozu M.: “The clinical characteristics and early detection of postpartum choriocarcinoma”. Int. J. Gynecol. Cancer, 2015, 25, 926.

[16] Seckl M.J., Sebire N.J., Berkowitz R.S.: “Gestational trophoblastic disease”. Lancet, 2010, 376, 717.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top