Small cell carcinoma of the endometrium mixed with endometriod adenocarcinoma: a case report

Small cell neuroendocrine carcinoma of the female genital tract is very rare, with highly aggressiveness and poor clinical outcome. It can be mostly found in the cervix, followed by the ovaries. Endometrial small cell carcinoma (SCC) is extremely rare in perimenopausal or postmenopausal women. Here, the authors present a case of a 59-year-old postmenopausal woman, who had experienced vaginal bleeding and abdominal pain for a long time. After undergoing a hysteroscopy-guided biopsy which revealed small cell neuroendocrine carcinoma of the endometrium, she received a total abdominal hysterectomy with bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and para-aortic lymphadenectomy. Her final FIGO Stage was IA. Recommendation from the tumor board was chemotherapy treatment after surgery, but this patient refused to take any measures. The patient experienced no indication of a tumor in the abdomen 14 months after the diagnosis. Endometrial small carcinoma is a very rare and aggressive cancer. The prognosis is unfavorable but timely surgical treatment and early pathological stage may improve the clinical outcome.

Small cell carcinoma; Endometrium; Endometrial cancer; Immunohistochemical staining

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