CD34-positive uterine lipoleiomyoma in a postmenopausal woman with chronic glomerulonephritis

Lipoleiomyomas are rare benign mesenchymal tumors in the uterus that are composed of an admixture of smooth muscle and adipose tissue. Their pathogenesis is still controversial, although many theories have been proposed so far. Herein, the authors report the first case of a CD-34 positive lipoleiomyoma in a patient with chronic glomerulonephritis. A 60-year-old postmenopausal woman with chronic glomerulonephritis and hyperlipidemia underwent a screening ultrasonographic examination, and a mass located on the left side of the uterus was detected. She underwent hysterectomy and bilateral salpingo-oophorectomy. Pathologically, the tumor was com-posed of an admixture of smooth muscle cells and mature adipocytes. The diagnosis of lipoleiomyoma was made. Immunohistochem-ically, some smooth muscle cells in the tumor were positive for CD34, which is one of the mesenchymal stem cell markers. The significance of CD34 positivity remains obscure. Further studies are needed to clarify the role of CD34-positive cells in the pathogenesis of lipoleiomyomas.

CD34; Chronic glomerulonephritis; Lipoleiomyoma; Uterus.

[1] Akbulut M., Gündoğan M., Yörükoğlu A.: “Clinical and patho-logical features of lipoleiomyoma of the uterine corpus: a review of 76 cases”. Balkan Med. J., 2014, 31, 224.

[2] Oh S.R., Cho Y.J., Han M., Bae J.W., Park J.W., Rha S.H.: “Uterine Lipoleiomyoma in Peri or Postmenopausal Women”. J. Menopausal Med., 2015, 21, 165.

[3] Fujiwaki R., Ohnuma H., Miura H., Sawada K.: “Uterine lipoleiomyoma in an elderly patient: a case report”. Arch. Gynecol. Obstet., 2008, 277, 471.

[4] Aung T., Goto M., Nomoto M., Kitajima S., Douchi T., Yoshi-naga M., Yonezawa S.: “Uterine lipoleiomyoma: a histopathological review of 17 cases”. Pathol. Int., 2004, 54, 751.

[5] Wang X., Kumar D., Seidman J.D.: “Uterine lipoleiomyomas: a clinicopathologic study of 50 cases”. Int. J. Gynecol. Pathol., 2006, 25, 239.

[6] Salman M.C., Atak Z., Usubutun A., Yuce K.: “Lipoleiomy-oma of broad ligament mimicking ovarian cancer in a post-menopausal patient: case report and literature review”. J. Gynecol. Oncol., 2010, 21, 62.

[7] Akbulut M., Soysal M.E., Duzcan S.E.: “Giant lipoleiomyoma of the uterine corpus”. Arch. Gynecol. Obstet., 2008, 278, 291.

[8] Terada T.: “Huge lipoleiomyoma of the uterine cervix”. Arch. Gynecol. Obstet., 2011, 283, 1169.

[9] Pedeutour F., Quade B.J., Sornberger K., Tallini G., Ligon A. H., Weremowicz S., Morton C.C.: “Dysregulation of HMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14”. Genes Chromosomes Cancer, 2000, 27, 209.

[10] Hu J., Surti U., Tobon H.: “Cytogenetic analysis of a uterine lipoleiomyoma”. Cancer Genet. Cytogenet., 1992, 62, 200.

[11] Havel G., Wedell B., Dahlenfors R., Mark J.: “Cytogenetic re-lationship between uterine lipoleiomyomas and typical leiomyomas”. Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol., 1989, 57, 77.

[12] Yin P., Ono M., Moravek M.B., Coon J.S. 5th, Navarro A., Monsivais D., et al.: “Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo”. J. Clin. Endocrinol. Metab., 2015, 100, E601.

[13] Blandamura S., Florea G., Chiarelli S., Rondinelli R., Ninfo V.: “Myometrial leiomyoma with chondroid lipoma-like areas”. Histopathology, 2005, 46, 596.

[14] Robinson D.R., Wu Y.M., Kalyana-Sundaram S., Cao X., Lon-igro R.J., Sung Y.S., et al.: “Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing”.

[15] Yoshida A., Tsuta K., Ohno M., Yoshida M., Narita Y., Kawai A., et al.: “STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors”. Am J Surg Pathol., 2014, 38, 552.