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Sertoli-Leydig cell tumor characterized by hyperestrogenism in a postmenopausal woman: a case report and review of the literature

  • L. Wang1,2,3,4
  • A. Yao1
  • A. Zhang1
  • P. Qu5,*,

1The Third Central Clinical College of Tianjin Medical University, Tianjin

2Tianjin Key Laboratory of Artificial Cell, Tianjin (China)

3Artificial Cell Engineering Technology Research Center of Public Health Ministry, Tianjin

4Tianjin Institute of Hepatobiliary Disease, Tianjin

5Tianjin Central Hospital of Gynecology and Obstetrics, Tianjin (China)

DOI: 10.12892/ejgo4732.2019 Vol.40,Issue 3,June 2019 pp.502-505

Published: 10 June 2019

*Corresponding Author(s): P. Qu E-mail:


Sertoli-Leydig cell tumor (SLCT) is a rare neoplasm from the group of sex-stromal tumors of ovary, which accounts for < 0.5% of all primary ovarian tumors. The tumor can occur in all ages but is more often seen in young women at the mean age of 25 years. Less than 10% of the SLCTs occur before menarche or after menopause. Although most SLCTs have a good prognosis if detected in Stage I, but the most common are those with moderate or poor differentiation. In order to monitor the risk of disease recurrence, close followup is required. In this article the rare case of SLCT in a 62-year-old woman characterized by postmenopausal bleeding and hyperestrogenism was reported, The clinical and pathological characteristics were described. Clinicians should consider that patients with postmenopausal bleeding and hyperestrogenism should be highly suspicious of SLCT, and more prospective studies on the diagnosis and the course of the diseases are needed.


Sertoli-Leydig cell tumor; Hyperestrogenism; Postmenopausal bleeding.

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L. Wang,A. Yao,A. Zhang,P. Qu. Sertoli-Leydig cell tumor characterized by hyperestrogenism in a postmenopausal woman: a case report and review of the literature. European Journal of Gynaecological Oncology. 2019. 40(3);502-505.


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