Long non-coding RNA BANCR contributes to cervical adenocarcinoma migration by affecting epithelial-mesenchymal transition

Purpose of Investigation: The BRAF-activated non-coding RNA (BANCR) functions are both an oncogene and a tumor suppressor; however, little is known about the role of BANCR in the development of cervical adenocarcinoma. Materials and Methods: The authors investigated BANCR’s role in cervical adenocarcinoma by assessing BANCR levels in cervical adenocarcinoma and matched adjacent normal tissues from nine patients using qRT-PCR. They also used lentiviral vectors to establish cervical adenocarcinoma cell lines to investigate the effects of BANCR knockdown on cancer cell proliferation, apoptosis, and migration. Results: RT-PCR results showed that BANCR was frequently overexpressed in cancer tissues and cervical adenocarcinoma Hela cells. Knockdown of BANCR inhibited the migration of Hela cells in vitro. Further investigation into the mechanisms responsible for the migration effects revealed that BANCR induced the epithelial-mesenchymal transition (EMT) in Hela cells. Conclusion: These results revealed the important role of BANCR in the molecular etiology of cervical adenocarcinoma and implied the potential application of BANCR in cervical adenocarcinoma therapy.

Cervical adenocarcinoma; Long non-coding RNA; BANCR; migration; EMT.

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