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Persistent low-grade endometrial stromal tumor during two consecutive pregnancies-a case report and review of

literature

  • M.W. Lui1,*,
  • P.P.C. Ip2
  • E.Y.P. Lee3
  • K.Y. Tse1
  • H.Y.S. Ngan1

1Department of Obstetrics and Gynaecology, (Hong Kong)

2Department of Pathology, (Hong Kong)

3Department of Diagnostic Radiology,Queen Mary Hospital, the University of Hong Kong (Hong Kong)

DOI: 10.12892/ejgo4772.2019 Vol.40,Issue 6,December 2019 pp.1083-1086

Published: 10 December 2019

*Corresponding Author(s): M.W. Lui E-mail: luimanwa@gmail.com

Abstract

The authors report a case of persistent endometrial stromal tumour during two consecutive pregnancies. The diagnosis of endometrial stromal sarcoma (ESS) is difficult by fragmented tissue. There were a total of 19 reported cases of pregnancy after conservative man-agement of endometrial stromal sarcoma. Monitoring of disease during pregnancy is challenging, although most patients remain in a stable condition with a follow-up duration of 2-60 months. Although the present patient had a favorable disease outcome despite having co-existing ESS sustained throughout two term pregnancies, the current evidence on the safety of this approach is still scarce and thor-ough counseling is mandatory if any young patients wish to retain their fertility potential.

Keywords

Endometrial stroma tumour; Fertility-sparing surgery; Pregnancy.

Cite and Share

M.W. Lui,P.P.C. Ip,E.Y.P. Lee,K.Y. Tse,H.Y.S. Ngan. Persistent low-grade endometrial stromal tumor during two consecutive pregnancies-a case report and review of literature. European Journal of Gynaecological Oncology. 2019. 40(6);1083-1086.

References

[1] Amant F., Floquet A., Friedlander M., Kristensen G., Mahner S., Nam E.J., et al.: “Gynecologic Cancer InterGroup (GCIG) consensus review for endometrial stromal sarcoma”. Int. J. Gynecol. Cancer, 2014, 24, S67.

[2] Rauh-Hain J.A., del Carmen M.G.: “Endometrial stromal sarcoma: a systematic review”. Obstet. Gynecol., 2013, 122, 676.

[3] Network NCC: “Uterine Neoplasms (Version 2.2015)”.

[4] Tse K.Y., Crawford R., Ngan H.Y.: “Staging of uterine sarcomas”. Best Pract. Res. Clin. Obstet. Gynaecol., 2011, 25, 733.

[5] Baker P., Oliva E.: “Endometrial stromal tumours of the uterus: a practical approach using conventional morphology and ancillary techniques”. J. Clin. Pathol., 2007, 60, 235.

[6] Chan J., Kawar N., Shin J., Osann K., Chen L., Powell C., et al.: “Endometrial stromal sarcoma: a population-based analysis”. Br. J. Cancer, 2008, 99, 1210.

[7] Koskas M., Morice P., Yazbeck C., Duvillard P., Walker F., Madele-nat P.: “Conservative management of low-grade endometrial stromal sarcoma followed by pregnancy and severe recurrence”. Anticancer Res., 2009, 29, 4147.

[8] Yan L., Tian Y., Fu Y., Zhao X.: “Successful pregnancy after fertil-ity-preserving surgery for endometrial stromal sarcoma”. Fertil. Steril., 2010, 93, 269.e1.

[9] Delaney A.A., Gubbels A.L., Remmenga S., Tomich P., Molpus K.: “Successful pregnancy after fertility-sparing local resection and uter-ine reconstruction for low-grade endometrial stromal sarcoma”. Ob-stet. Gynecol., 2012, 120, 486.

[10] Sánchez-Ferrer M., Machado-Linde F., Ferri-Ñíguez B., Sánchez-Ferrer M., Parrilla-Paricio J.: “Reproductive outcome after uterine-sparing surgery for endometrial stromal sarcoma”. Gynecol. Oncol. Case Rep., 2013, 3, 4.

[11] Jain P.S., Jariwala M.C.: “Successful Pregnancy with Endometrial Stromal Sarcoma (ESS)”. J. Obstet. Gynaecol. India, 2014, 64, 297.

[12] Noventa M., Gizzo S., Conte L., Dalla Toffola A., Litta P., Saccardi C.: “Fertility sparing surgery in young women affected by endome-trial stromal sarcoma: an oncologic dilemma or a reliable option? re-view of literature starting from a peculiar case”. Onco. Targets Ther., 2015, 8, 29.

[13] Bai H., Yang J., Cao D., Huang H., Xiang Y., Wu M., et al.: “Ovary and uterus-sparing procedures for low-grade endometrial stromal sarcoma: A retrospective study of 153 cases”. Gynecol. Oncol., 2014, 132, 654.

[14] Lissoni A., Cormio G., Perego P., Gabriele A., Cantu M., Bratina G.: “Conservative management of endometrial stromalsarcoma in young women”. Int. J. Gynecol. Cancer, 1997, 7, 364.

[15] Dong R., Pang Y., Mao H., Yang N., Liu P.: “Successful pregnancy following conservative management of low-grade endometrial stro-mal sarcoma: A case report”. Oncol. Lett., 2014, 7, 1039.

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