Uterine smooth muscle tumor of uncertain malignant potential

Uterine smooth muscle tumor of uncertain malignant potential (STUMP) are uterine neoplasms with mesenchymal characteristics between benign leiomyomas and malignant leiomyosarcomas. A 41-year-old patient sought the Gynecology and Obstetrics Service of the Federal University of the Triângulo Mineiro for parous myoma and severe anemia.The patient underwent abdominal hysterectomy and the anatomicopathologic results showed mild nuclear atypia, hypercellularity, and foci of necrosis, which confirmed the diagnosis of STUMP. The patient was followed up for 45 months without recurrence of the disease.

Smooth muscle tumor; Uterine neoplasms; Leiomyoma; STUMP; Uterine cancer.

[1] Kotsopoulos I.C., Barbetakis N., Asteriou C., Voutsas M.G.: “Uterine smooth muscle tumor of uncertain malignant potential: A rare cause of multiple pulmonary nodules”. Indian J. Med. Paediatr. Oncol., 2012, 33, 176.

[2] Ünver N.U., Acikalin M.F., Öner Ü., Ciftci E., Ozalp S.S., Colak E.: “Differential expression of P16 and P21 in benign and malignant uterine smooth muscle tumors”. Arch. Gynecol. Obstet., 2011, 284, 483.

[3] Zaloudek C.J., Hendrickson M.R., Robert A.: “Mesenchymal tumors of the uterus”. In: Kurman R.J., (ed). Blaustein’s pathology of the fe-male genital tract. 6th ed. New York: Springer, 2011. 471.

[4] Kempson R.L.: “Sarcomas and related neoplasms”. In: Norris H.J., Hertig A.T., Abell M.R., (eds). The Uterus. Baltimore: Williams & Wilkins, 1973.

[5] Tavassoli F.A., Devilee P.: “World Health Organization Classifica-tion of Tumours: Tumours of the Breast and Female Genital Or-gans”. Lyon: International Agency for Research on Cancer Press 2003, 236.

[6] Berretta R., Rolla M., Merisio C., Giordano G., Nardelli G.B.: “Uter-ine smooth muscle tumor of uncertain malignant potential: a three-case report”. Int. J. Gynecol. Cancer, 2008, 18, 1121.

[7] Bell S.W., Kempson R.L., Hendrickson M.R.: “Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases”. Am. J. Surg. Pathol., 1994, 18, 535.

[8] Mittal K., Demopoulos R.I.: “MIB-1 (KI-67), p53, estrogen receptor, and progesterone receptor expression in uterine smooth muscle tu-mors”. Hum. Pathol., 2001, 32, 984.

[9] Malon C., Brachtel E., Cosatto E.: “Mitotic figure recognition: agree-ment among pathologists and computerized detector”. Anal. Cell. Pathol. (Amst.), 2012, 35, 97.

[10] Guntupalli S.R., Ramirez P.T., Anderson M.L., Milan M.R., Bodurka D.C., Malpica A.: “Uterine smooth muscle tumor of uncertain ma-lignat potential: a retrospective analysis”. Gynecol. Oncol., 2009, 113, 324.

[11] Atkins K.A., Arronte N., Darus C.J., Rice L.W.: “The Use of p16in enhancing the histologic classification of uterine smooth-muscle tu-mors”. Am. J. Surg. Pathol., 2008, 32, 98.

[12] D’Angelo E., Prat J.: “Uterine sarcomas: a review”. Gynecol. Oncol., 2010, 116, 131.

[13] Ip P.P., Tse K.Y., Tam K.F.: “Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of se-lected variants with emphasis on recent advances and unusual mor-phology that may cause concern for malignancy”. Adv. Anat. Pathol., 2010, 17, 91.

[14] Shapiro A., Ferenczy A., Turcotte R., Bruchim I., Gotlieb W.H.: “Uterine smooth-muscle tumor of uncertain malignat potential metastasizing to the humerus as a high-grade leiomyosarcoma”. Gy-necol. Oncol., 2004, 94, 818.

[15] Peters W.A. 3rd., Howard D.R., Andersen W.A., Figge D.C.: “Uter-ine smooth-muscle tumors of uncertain malignant potencial”. Obstet. Gynecol., 1994, 83, 1015.

[16] Al-Nafussi A.: “Uterine smooth-muscle tumours: pratical approach to diagnosis”. Curr. Diagn. Pathol., 2004, 10, 140.