One step nucleic acid amplification (OSNA): one step ahead in gynecological surgical oncology

Neoplastic spread to lymph nodes is one of the most important prognostic factors in female cancer and one of the well known TNM classification parameters, together with tumor size and distant metastases. The nodal status is in faet a significant predictor, which supports clinicians to decide on the most appropriate surgical approach and subsequent therapy. The precise intraoperative assessment of sentinel lymph node and eventual metastatic burden is therefore decisive for providing high diagnostic quality and reliable staging. Since methodologies differ across ìnstìtutions, standardization of results is also a challenge. Today, one step nucleic acid amplificatìon (OSNA) meets all these needs.

One-step nucleic acid amplification (OSNA); Sentinel lymph node; Sentinel lymph node biopsy; Vulvar cancer; Gynecological surgical oncology

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