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Open Access Special Issue

Circulating tumor cells in metastatic breast cancer: ready for clinical practice?

  • Laura Brus1
  • Donata Grimm-Glang2,3
  • Natalia Krawczyk4
  • Tanja Fehm4
  • Achim Rody2
  • Peter Paluchowski1
  • Maggie Banys-Paluchowski2,*,

1Department of Gynecology and Obstetrics, Regio Klinikum Pinneberg, 25421 Pinneberg, Germany

2Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus-Lübeck, 23538 Lübeck, Germany

3Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany

4Department of Gynecology and Obstetrics, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany

DOI: 10.22514/ejgo.2022.007 Vol.43,Issue 3,June 2022 pp.4-8

Submitted: 13 December 2021 Accepted: 10 May 2022

Published: 15 June 2022

(This article belongs to the Special Issue Breast Cancer)

*Corresponding Author(s): Maggie Banys-Paluchowski E-mail:


Circulating tumor cells (CTCs) have emerged as a promising new biomarker in breast cancer and various settings in which liquid biopsy may improve diagnostics are currently under discussion. In patients with metastatic disease, high CTC counts have been shown to predict poor prognosis with level I evidence. Persistence of elevated CTC numbers after begin of systemic treatment is associated with higher risk of progression. This review discusses current evidence on the clinical use of CTC diagnostics in metastatic breast cancer.


circulating tumor cells; CTCs; liquid biopsy; breast cancer; metastatic breast cancer; therapy interventions

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Laura Brus,Donata Grimm-Glang,Natalia Krawczyk,Tanja Fehm,Achim Rody,Peter Paluchowski,Maggie Banys-Paluchowski. Circulating tumor cells in metastatic breast cancer: ready for clinical practice?. European Journal of Gynaecological Oncology. 2022. 43(3);4-8.


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