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Systematic reviews

Open Access

Traditional Chinese medicine for bone metastasis of breast cancer: a systematic review and meta-analysis

  • Cheng Qian1
  • Huwei Bian1
  • Tao Jiang1,*,

1Department, Changzhou Hospital Affiliated to Nanjing University of Chinese Medicine, 213004 Changzhou, Jiangsu Province, China

DOI: 10.22514/ejgo.2022.053 Vol.43,Issue 6,December 2022 pp.13-20

Submitted: 26 June 2022 Accepted: 08 July 2022

Published: 15 December 2022

*Corresponding Author(s): Tao Jiang E-mail:


Breast cancer incidence is increasing, and bone metastases in terminal breast cancer cause considerable patient suffering. Many researchers have reported that traditional Chinese medicine (TCM) benefits breast cancer patients with bone metastasis. However, no conclusive evidence can be proved for its effects. This paper assesses the effects of TCM on bone metastasis of breast cancer. Databases were searched independently for randomized controlled trials about TCM for bone metastasis of breast cancer by two reviewers. The effective rate was assessed as the primary outcome. Patient’s condition and adverse events were assessed as secondary outcomes. Thirteen articles were included in our meta-analysis. The results showed that TCM is effective for treating bone metastasis of breast cancer (RR (Risk ratio) = 1.10, 95% CI (Confidence interval)(1.04, 1.16), p < 0.05). TCM can improve metastasis to the bone in breast cancer (RR = 1.52, 95% CI (1.33, 1.74), p < 0.05). TCM also relieved pain in patients with bone metastasis of breast cancer (RR = 1.41, 95% CI (1.22, 1.63), p < 0.05). Six studies reported adverse events (RR = 0.41, 95% CI (0.28, 0.62), p < 0.05). This shows that adjuvant treatment with TCM can reduce the incidence of adverse reactions. TCM treatment is an effective and safe adjuvant therapy for bone metastasis in breast cancer patients.


Traditional Chinese medicine; Bone metastasis; Breast cancer; Meta-analysis; Systematic review

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Cheng Qian,Huwei Bian,Tao Jiang. Traditional Chinese medicine for bone metastasis of breast cancer: a systematic review and meta-analysis. European Journal of Gynaecological Oncology. 2022. 43(6);13-20.


[1] Liang Y, Zhang H, Song X, Yang Q. Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets. Seminars in Cancer Biology. 2020; 60: 14–27.

[2] Chen Z, Wang M, De Wilde RL, Feng R, Su M, Torres-de la Roche LA, et al. A machine learning model to predict the triple negative breast cancer immune subtype. Frontiers in Immunology. 2021; 12: 749459.

[3] Brook N, Brook E, Dharmarajan A, Dass CR, Chan A. Breast cancer bone metastases: pathogenesis and therapeutic targets. The International Journal of Biochemistry & Cell Biology. 2018; 96: 63–78.

[4] Chen YC, Sosnoski DM, Mastro AM. Breast cancer metastasis to the bone: mechanisms of bone loss. Breast Cancer Research. 2010; 12: 215.

[5] Salvador F, Llorente A, Gomis RR. From latency to overt bone metastasis in breast cancer: potential for treatment and prevention. The Journal of Pathology. 2019; 249: 6–18.

[6] Hong S, Youk T, Lee SJ, Kim KM, Vajdic CM. Bone metastasis and skeletal-related events in patients with solid cancer: a Korean nationwide health insurance database study. PLoS One. 2020; 15: e0234927.

[7] Yousefi M, Nosrati R, Salmaninejad A, Dehghani S, Shahryari A, Saberi A. Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis. Cellular Oncology. 2018; 41: 123–140.

[8] Haider MT, Ridlmaier N, Smit DJ, Taipaleenmäki H. Interleukins as mediators of the tumor cell-bone cell crosstalk during the initiation of breast cancer bone metastasis. International Journal of Molecular Sciences. 2021; 22: 2898.

[9] Ye L, Jia Y, Ji KE, Sanders AJ, Xue K, Ji J, et al. Traditional Chinese medicine in the prevention and treatment of cancer and cancer metastasis. Oncology Letters. 2015; 10: 1240–1250.

[10] Kar S, Katti DR, Katti KS. Bone interface modulates drug resistance in breast cancer bone metastasis. Colloids and Surfaces B: Biointerfaces. 2020; 195: 111224.

[11] Gu R, Xu S, Li Z, Gu Y, Sun Z. The safety and effectiveness of rehabilitation exercises on COVID-19 patients. Medicine. 2020; 99: e21373.

[12] Higgins J, Green S. Chapter 8: assessing risk of bias in included studies. Cochrane Handbook for Systematic Reviews of Interventions. 5.1.0 edn. John Wiley & Sons Ltd: The Atrium. 2011.

[13] Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2016; 354: i4086.

[14] Renjun G, Ziyun L, Xiwu Y, Wei W, Yihuang G, Chunbing Z, et al. Psychological intervention on COVID-19. Medicine. 2020; 99: e20335.

[15] Gu R, Chen H, Adhikari A, Gu Y, Kwong JSW, Li G, et al. Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age. Cochrane Database of Systematic Reviews. 2021; 2021: CD014847.

[16] Wenjuan Jia, Fei Tian, Xiuling Xing, Li Zhang. Clinical study on Xihuang Pill Combined with zoledronic acid injection in the treatment of bone metastases from breast cancer. World Science and Technology-Modernization of Traditional Chinese Medicine. 2009; 450–453. (In Chinese)

[17] Ying Wang, Lin Song, Jianxiong Cao. Clinical observation on the treatment of bone metastasis of breast cancer with Zhuanggu Zhentong capsule combined with bisphosphate. Inner Mongol Journal of Traditional Chinese Medicine. 2014; 74–75. (In Chinese)

[18] Lizhuo Zhang. Clinical effect of modified Yanghe Decoction on bone metastasis of breast cancer. World Latest Medical Information Digest. 2018; 158–159.

[19] Ying Fang, Jin-Hui Hu, Zheng Yang, Bo Yuan, Xi Wang, De-Guo Liu, et al. Clinical study on Bushen Huoxue Decoction Combined with zoledronic acid in the treatment of bone metastasis of breast cancer. Journal of Traditional Chinese Medicine University of Hunan. 2015; 55–57. (In Chinese)

[20] Yang Li, Lizhong Huang, Hui Gong, Yujie Xiao, Yunqi Wang, Hui Liang. Clinical observation of supplemented Yanghe decoction on the treatment of bone metastasis of breast cancer. Central South Pharmacy. 2015; 1105–1108.

[21] Ke Wang. Clinical effect of Yishen Recipe on bone metastasis of kidney deficiency type breast cancer [master’s thesis]. Henan University of Traditional Chinese Medicine. 2016. (In Chinese)

[22] Deming Song. Clinical observation on Liuwei Dihuang Pill in treating bone metastasis of breast cancer with kidney yin deficiency [master’s thesis]. Liaoning University of Traditional Chinese Medicine. 2016. (In Chinese)

[23] Bingbing Shen. Effect of Yishen Recipe on serum TGF-β_1 in patients with bone metastasis of kidney deficiency type breast cancer [master’s thesis]. Henan University of Traditional Chinese Medicine. 2016. (In Chinese)

[24] Xiangyue Meng. The clinical efficacy of jiawei yanghe decoction in treatment of bone metastasis of breast cancer. China Foreign Medical Treatment. 2017; 159–161. (In Chinese)

[25] Haifu Huang. Effect of Duhuo Jisheng Decoction on bone related events in patients with bone metastasis of breast cancer. Chinese Journal of Basic Chinese Medicine. 2017; 1267–1268. (In Chinese)

[26] Xin Long, Zhimin Zhang. Clinical evaluation of modified Baizhu Fuzi Decoction in the treatment of bone metastasis of breast cancer. Inner Mongolia traditional Chinese medicine. 2017; 8: 42–43. (In Chinese)

[27] Penghui Wang. Clinical effect of modified Baizhu Fuzi Decoction on bone metastasis of breast cancer. Electronic Journal of Clinical Medical Literature. 2019; 174–177. (In Chinese)

[28] Xin Shen, Jiajia Ma, Yang Xu, Yi Zhang, Hai Shi. Curative effect of Tiaogan Lishen Jiedu decoction on bone metastasis after breast cancer surgery. Shaanxi Journal of Traditional Chinese Medicine. 2019; 1594–1597. (In Chinese)

[29] Tao W, Jiang H, Tao X, Jiang P, Sha L, Sun X. Effects of acupuncture, tuina, tai chi, qigong, and traditional chinese medicine five-element music therapy on symptom management and quality of life for cancer patients: a meta-analysis. Journal of Pain and Symptom Management. 2016; 51: 728–747.

[30] Wang K, Chen Q, Shao Y, Yin S, Liu C, Liu Y, et al. Anticancer activities of TCM and their active components against tumor metastasis. Biomedicine & Pharmacotherapy. 2021; 133: 111044.

[31] Akagi H, Shimada A, Chin K, Domoto H. Successful stabilization of symptomatic bone marrow metastasis two times in a breast cancer patient. Anticancer Research. 2021; 41: 3139–3144.

[32] Higgins JPT, Savović J, Page MJ, Elbers RG, Jac S. Chapter 8: assessing risk of bias in a randomized trial. Cochrane Handbook for Systematic Reviews of Interventions (pp. 205-228). 6th edn. John Wiley & Sons Ltd: Cochrane. 2019.

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