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Original Research

Open Access

Application and comparison of several machine learning methods in the prognosis of cervical cancer

  • Yawen Ling1,†
  • Weiwei Zhang2,†
  • Zhidong Li1
  • Xiaorong Pu1
  • Yazhou Ren1,3,*,

1School of Computer Science and Engineering, University of Electronic Science and Technology of China, 611731 Chengdu, Sichuan, China

2Cancer prevention and treatment institute of Chengdu, Department of oncology, Chengdu Fifth People's Hospital/The Second Clinicical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, 611137 Chengdu, Sichuan, China

3Institute of Electronic and Information Engineering of UESTC in Guangdong, 523808 Dongguan, Guangdong, China

DOI: 10.22514/ejgo.2022.056 Vol.43,Issue 6,December 2022 pp.34-44

Submitted: 29 June 2022 Accepted: 02 August 2022

Published: 15 December 2022

*Corresponding Author(s): Yazhou Ren E-mail: yazhou.ren@uestc.edu.cn

† These authors contributed equally.

Abstract

Accurate prognosis of cervical cancer in the clinical setting is challenging because of the complexity of the causative factors. Considering the drawbacks of the widely used Cox proportional hazards model, such as the inability to fully use the information and the possible failure to achieve the best fit, several new attempts based on machine learning have been developed to find better prognostic prediction models. However, the application of these attempts is often limited, because they often rely on public databases. Therefore, for cervical cancer, there is a need to explore the value of machine learning in terms of its practical application in prognostic prediction. In this study, we introduced several machine learning methods including k-nearest neighbors (KNN), decision tree (DT), logistic regression (LR), support vector machine (SVM), random forest (RF), extreme gradient boosting (XGBoost) and light gradient boosting machine (LightGBM) to predict the survival of patients by using the real-world pathological data of 216 patients collected from the Fifth People’s Hospital of Chengdu. The experimental results showed that these methods have a promising application value in the prediction of overall survival (OS) of patients with cervical cancer (KNN: F1-score = 0.95, Accuracy = 0.93, DT: F1-score = 0.94, Accuracy = 0.92, LR: F1-score = 0.92, Accuracy = 0.90, SVM: F1-score = 0.94, Accuracy = 0.92, RF: F1-score = 0.96, Accuracy = 0.95, XGBoost: F1-score = 0.96, Accuracy = 0.95, LightGBM: F1-score = 0.96, Accuracy = 0.95). Moreover, XGBoost and LightGBM gave the importance of the clinical indicators associated with cervical cancer, whose correlation with OS and progression-free survival (PFS) can be further obtained. Thus, the predictors of OS and PFS were successfully identified. Finally, the results were confirmed by the Cox proportional hazards model. These results indicated that machine learning methods can accurately predict the OS of patients with cervical cancer. Moreover, the methods can be used to analyze the correlation between clinical indicators and OS or PFS to help doctors make more accurate decisions in a clinical setting.


Keywords

Cervical cancer; Machine learning; Prognosis; Overall survival; Progression-free survival


Cite and Share

Yawen Ling,Weiwei Zhang,Zhidong Li,Xiaorong Pu,Yazhou Ren. Application and comparison of several machine learning methods in the prognosis of cervical cancer. European Journal of Gynaecological Oncology. 2022. 43(6);34-44.

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