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Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary-pulmonary type (SCCOPT): a case report and literature review

  • Qiuyang Jing1
  • Ying He1,*,

1Department of Pathology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, 610041 Chengdu, Sichuan, China

DOI: 10.22514/ejgo.2022.065 Vol.43,Issue 6,December 2022 pp.113-121

Submitted: 14 September 2022 Accepted: 18 November 2022

Published: 15 December 2022

*Corresponding Author(s): Ying He E-mail: heying626@163.com

Abstract

Serous carcinoma arising in adenomyosis is rare, with only 8 cases reported in the literature. Primary small cell carcinoma of the ovary-the pulmonary type (SCCOPT) is a rare and aggressive entity associated with poor outcomes and limited treatment options. The presence of two malignant tumors synchronously happening in one patient has never been reported before. In this study, we summarized and analyzed the clinicopathological features of a serous carcinoma arising in adenomyosis synchronous with SCCOPT and reviewed the corresponding literature. A 60-year-old postmenopausal woman presented to our hospital with abdominal distension, abdominal pain, and constipation. A colonoscopy and lung computed tomography (CT) scan showed no abnormalities. Ultrasonography and CT scans revealed a solid-cystic mass in the pelvic cavity, with a slightly thickened uterine myometrium at the fundus with heterogeneous echo. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and pelvic and para-aortic lymphadenectomy, and the final pathology showed serous carcinoma originating from adenomyosis, while the eutopic endometrium and both fallopian epithelia had no cancer infiltrations. The solid-cystic mass in the right ovary was diagnosed with SCCOPT, which was found to metastasize to the uterine myometrium. The prognosis of previously reported cancers of adenomyosis origin and SCCOPT were poor, while our case was alive without disease during an 18-month follow-up. Findings from this case report could expand our recognition on the coexistence of serous carcinoma arising in adenomyosis with small cell carcinoma of the ovary-pulmonary type.


Keywords

Serous carcinoma; Adenomyosis; Malignant transformation; Small cell carcinoma of the ovary; Pulmonary type; Immunohistochemistry


Cite and Share

Qiuyang Jing,Ying He. Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary-pulmonary type (SCCOPT): a case report and literature review. European Journal of Gynaecological Oncology. 2022. 43(6);113-121.

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