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Immunohistological study of ovarian mature cystic teratoma with extremely elevated SCC antigen level

  • Kyousuke Takeuchi1,*,
  • Akari Shirakuni1
  • Ai Yoshida1
  • Makoto Sugimoto1
  • Sohei Kitazawa2
  • Hiroki Morita3

1Department of Obstetrics and Gynecology, National Hospital Organization Kobe Medical Center, 654-0155 Kobe, Japan

2Department of Pathology, School of Medicine, Ehime University, 791-0295 Toon, Japan

3Department of Obstetrics and Gynecology, Kohnan Medical Center, 658-0064 Kobe, Japan

DOI: 10.22514/ejgo.2023.030 Vol.44,Issue 2,April 2023 pp.121-125

Submitted: 05 January 2023 Accepted: 14 February 2023

Published: 15 April 2023

*Corresponding Author(s): Kyousuke Takeuchi E-mail:


Squamous cell carcinoma (SCC) antigen is a reliable tumor marker for various cancers, including cervical cancer and lung cancer, and was recently reported to correlate with the severity of inflammatory skin diseases such as atopic dermatitis. Herein, we present a case of a 47-year-old female patient who presented with acute abdomen rupture due to a mature cystic teratoma of the ovary, approximately 11 cm in diameter on imaging examination, prompting emergency laparoscopic surgery. The patient had no symptoms of atopic dermatitis. The operative findings showed no evidence of torsion, but the membrane was partially ruptured, leading to the leakage of the cyst contents. The operation was completed after excising the adnexa and intraperitoneal lavage. The postoperative results revealed a markedly high serum SCC antigen level of 55.3 ng/dL, which was normalized at 2 months postoperatively. Postoperative histopathological examination revealed no squamous cell carcinoma component but a marked lymphocytic infiltrate under the squamous epithelium, suggesting a high degree of inflammation. Additionally, immunostaining demonstrated a cluster of differentiation (CD) 8+ lymphocyte predominance over CD4+ lymphocytes, similar to the histology of atopic dermatitis. Altogether, our findings suggest that the abnormally high SCC antigen levels might be attributed to the presence of severe inflammation in the mature cystic teratoma rather than an underlying malignancy and support the notion that SCC antigen may be a useful marker beyond its established role in cervical and lung cancers.


Mature cystic teratoma; SCC antigen; Atopic dermatitis-like inflammation of the ovary; Immunohistochemistry

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Kyousuke Takeuchi,Akari Shirakuni,Ai Yoshida,Makoto Sugimoto,Sohei Kitazawa,Hiroki Morita. Immunohistological study of ovarian mature cystic teratoma with extremely elevated SCC antigen level. European Journal of Gynaecological Oncology. 2023. 44(2);121-125.


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