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Association of HPV and sexually transmitted infections among patients with genital warts and asymptomatic individuals: a cross-sectional study

  • Eser Ağar1,*,
  • Seda Şahin Aker2

1Department of Vocational School of Health Services, Operating Room Services Division, Istanbul Gelisim University, 34310 Istanbul, Turkey

2Department of Gynecology and Obstetrics, Gynecologic Oncology Division, Kayseri City Hospital, 38080 Kayseri, Turkey

DOI: 10.22514/ejgo.2023.048 Vol.44,Issue 4,August 2023 pp.145-155

Submitted: 08 April 2023 Accepted: 09 May 2023

Published: 15 August 2023

*Corresponding Author(s): Eser Ağar E-mail:


STIs can impact HPV infection and persistence, potentially predisposing HPV-related cervical cancer development. This study examines HPV genotype prevalence and co-occurrence with other STIs to inform targeted prevention and treatment strategies for reducing cervical cancer incidence. 129 female patients aged 18–57 were enrolled based on the presence of anogenital warts, individuals with a history of risky sexual behaviors, having a partner with HPV infection, or voluntarily seeking HPV screening. Patients with a history of any STIs, prior HPV vaccination, systemic illnesses, or undergoing cancer treatment were excluded. Patients were divided into two groups: Genital warts group (31.8%) and asymptomatic group (68.2%). Among patients with genital warts, HPV types 6, 11, and 61 were prevalent, whereas in asymptomatic patients, HPV types 53, 31, and 16 were more common. The STI positivity rate among HPV-positive patients was 63.9%, significantly higher than HPV-negative cases. In the genital warts group at admission, Ureaplasma Parvum (UP) was the most common STI (40.0%), followed by Uraeplasma Urealyticum (UU) (28.5%), Mycoplasma Hominis (MH) (17.2%), and Chlamidia Trachomatis (CT) (11.4%). In the asymptomatic group, UP was also the most common STI (41.2%), followed by UU (17.6%), MH (15.8%), CT (9.7%), TV (6.2%), MG (5.3%), HSV-2 (2.6%), TP (0.8%), and NG (0.8%). The prevalence of UP was significantly higher (53.7%) in the HPV-positive group, suggesting a 6.96-fold greater risk of UP infection in individuals with HPV. This study demonstrates a high co-infection rate between HPV and UP, emphasizing the importance of genital infection screening for high-risk HPV-positive women. Further longitudinal research is needed to investigate the role of STIs as contributing factors in HPV-related cervical cancer development.


HPV genotypes; STI co-infections; Ureaplasma parvum; Cervical infections; Cervical cancer risk

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Eser Ağar,Seda Şahin Aker. Association of HPV and sexually transmitted infections among patients with genital warts and asymptomatic individuals: a cross-sectional study. European Journal of Gynaecological Oncology. 2023. 44(4);145-155.


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