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Chikusetsusaponin Iva induces apoptosis and inhibits proliferation in endometrial cancer via promoting reactive oxygen species (ROS) production
1Department of Gynecology, The First Hospital of Huai'an Affiliated to Nanjing Medical University, 223300 Huai’an, Jiangsu, China
DOI: 10.22514/ejgo.2023.068 Vol.44,Issue 4,August 2023 pp.164-169
Submitted: 30 May 2023 Accepted: 04 July 2023
Published: 15 August 2023
*Corresponding Author(s): Leilei Xu E-mail: xuleilei1230416@163.com
Endometrial carcinoma (EC) is an epithelial malignant tumor that occurs in the endometrium. It is of great significance to explore new targets for improving the prognosis of endometrial cancer. Chikusetsusaponin Iva (CHI) is a plant compound extracted from Panacis japonica which has multiple biological activities, including anti-inflammation and anti-tumor effects. However, its possible effects on EC are unclear. Herein, we found that CHI inhibited EC cell proliferation and cell cycle, confirmed by colony formation and flow cytometry (FCM) assays. The results further confirmed that CHI stimulated the apoptosis of EC cells. Furthermore, we noticed that CHI treatment induced reactive oxygen species (ROS) in EC cells. In addition, it could suppress the Microtubule-Associated Protein Kinase (MAPK) pathway in EC cells, thereby affecting cell proliferation and apoptosis. Therefore, CHI could serve as a potential drug for EC treatment.
Endometrial carcinoma (EC); Chikusetsusaponin Iva (CHI); Proliferation; Reactive oxygen species (ROS) production; MAPK pathway
Leilei Xu,Fu Hua,Changhua Li,Xiaoping Liu. Chikusetsusaponin Iva induces apoptosis and inhibits proliferation in endometrial cancer via promoting reactive oxygen species (ROS) production. European Journal of Gynaecological Oncology. 2023. 44(4);164-169.
[1] Tung HJ, Wu RC, Lin CY, Lai CH. Rare subtype of endometrial cancer: undifferentiated/dedifferentiated endometrial carcinoma, from genetic aspects to clinical practice. International Journal of Molecular Sciences. 2022; 23: 3794.
[2] Li J, Yang H, Zhang L, Zhang S, Dai Y. Metabolic reprogramming and interventions in endometrial carcinoma. Biomedicine & Pharmacotherapy. 2023; 161: 114526.
[3] Saldaña-Inda I, Tejada-Meza H, Sainz-Pardo A, Moreno-Loscertales C, Marta-Moreno J. Endovascular treatment for acute basilar artery occlusion: descriptive analysis of the experience in a comprehensive stroke centre. Signa Vitae. 2021; 17: 125–131.
[4] Goel P, Singh V, Sharma R, Chaudhary D, Chatterjee A, Dora T, et al. Early endometrial carcinoma: experience and outcomes. Journal of Cancer Research and Therapeutics. 2023; 19: S0.
[5] Lee C, Liu H, Khan S, Lee P, Huang K, Yen C. Vaginal natural orifice transvaginal endoscopic surgery (vNOTES) surgical staging for endometrial carcinoma: the feasibility of an innovative approach. Taiwanese Journal of Obstetrics and Gynecology. 2022; 61: 345–352.
[6] Kluska A, Tomasik B, Moszynska-Zielinska M, Zytko L, Tracz N, Spych M, et al. Prospective analysis of the impact of adjuvant treatment with external beam radiation therapy and vaginal brachytherapy on health-related quality of life in patients with early-stage endometrioid endometrial carcinoma. To be published in Ginekologia Polska. 2023.[Preprint].
[7] Xin Y, Yuan Q, Liu C, Zhang C, Yuan D. MiR-155/GSK-3beta mediates anti-inflammatory effect of Chikusetsusaponin IVa by inhibiting NF-κB signaling pathway in LPS-induced RAW264.7 cell. Scientific Reports. 2020; 10: 18303.
[8] Yin J, Seo CS, Hwang IH, Lee MW, Song KH. Anti-obesity activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds. Nutrients. 2018; 10: 1221.
[9] Yuan Q, Zhang D, Liu C, Zhang C, Yuan D. Chikusetsusaponin V Inhibits LPS-activated inflammatory responses via SIRT1/NF-kappaB signaling pathway in RAW264.7 cells. Inflammation. 2018; 41: 2149–2159.
[10] Zuo T, Zhang Z, Jiang P, Zhang R, Ni D, Yuan Y, et al. Characterization of chikusetsusaponin IV and V induced apoptosis in HepG2 cancer cells. Molecular Biology Reports. 2022; 49: 4247–4255.
[11] Chen X, Wu Q, Meng F, Tang Z, Chen X, Lin L, et al. Corrigendum: Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells. Phytomedicine. 2016; 23: 1555–1565.
[12] Wang S, Zeng M, Li B, Kan Y, Zhang B, Zheng X, et al. Raw and salt-processed achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway. Biomedicine & Pharmacotherapy. 2020; 129: 110403.
[13] Barra F, Evangelisti G, Ferro Desideri L, Di Domenico S, Ferraioli D, Vellone VG, et al. Investigational PI3K/AKT/mTOR inhibitors in development for endometrial cancer. Expert Opinion on Investigational Drugs. 2019; 28: 131–142.
[14] Králíčková M, Vetvicka V, Laganà AS. Endometrial cancer—is our knowledge changing? Translational Cancer Research. 2020; 9: 7734–7745.
[15] Pitakkarnkul S, Chanpanitkitchot S, Tangjitgamol S. Management of inoperable endometrial cancer. Obstetrics & Gynecology Science. 2022; 65: 303–316.
[16] Yang J, Qian S, Cai X, Lu W, Hu C, Sun X, et al. Chikusetsusaponin IVa butyl ester (CS-IVa-Be), a novel IL6R antagonist, inhibits IL6/STAT3 signaling pathway and induces cancer cell apoptosis. Molecular Cancer Therapeutics. 2016; 15: 1190–1200.
[17] Caeser R, Hulton C, Costa E, Durani V, Little M, Chen X, et al. MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer. iScience. 2021; 24: 103224.
[18] Wang W, Edington HD, Jukic DM, Rao UN, Land SR, Kirkwood JM. Impact of IFNalpha2b upon pSTAT3 and the MEK/ERK MAPK pathway in melanoma. Cancer Immunology, Immunotherap. 2008; 57: 1315–1321.
[19] Tong D, Xu E, Ge R, Hu M, Jin S, Mu J, et al. Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1alpha signaling pathway. Chemico-Biological Interactions. 2023; 380: 110536.
[20] Sun Q, Suo Y, Lv H, Wang Q, Yin H. Porphin e6 complex loaded with gold nanorod mesoporous silica enhances photodynamic therapy in ovarian cancer cells in vitro. Lasers in Medical Science. 2023; 38: 115.
[21] Qu J, Sun Y, Yang L, Niu X, Li L. Fucoxanthin prevents cell growth and induces apoptosis in endometrial cancer HEC-1A cells by the inhibition of the PI3K/Akt/mTOR pathway. Journal of Biochemical and Molecular Toxicology. 2022; 36: e23027.
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