Dezocine inhibits proliferation as well as migration of endometrial carcinoma in vitro
1Department of Anesthesiology, Yancheng First People’s Hospital, 224006 Yancheng, Jiangsu, China
2Department of Gynecology, Yancheng First People’s Hospital, 224006 Yancheng, Jiangsu, China
DOI: 10.22514/ejgo.2023.081 Vol.44,Issue 5,October 2023 pp.75-82
Submitted: 29 May 2023 Accepted: 20 July 2023
Published: 15 October 2023
Endometrial cancer (EC) includes several epithelial malignancies existed in the endometrium tissues. To improve the prognosis of EC, it is greatly needed to find new drugs. Dezocine, a organic compound, is an κ agonist and a µ receptor antagonist, is used in clinical anesthesia after cancer surgery with few side effects, and its anti-tumor effects have also been demonstrated in several tumors. However, the effects of Dezocine on EC progression have not been elusidated. Herein, we investigated the role of Dezocine in EC cell functions. Through a series of cellular assays, such as cell counting kit-8 (CCK-8), flow cytometry (FCM), transwell assays, we found that Dezocine suppressed the EC cell proliferation, and stimulated EC cell apoptosis in vitro. Furthermore, results revealed Dezocine restrained the motility, including migration and invasion of EC cells. Mechanically, Dezocine suppressed the Akt (protein kinase B, PKB)/mammalian target of rapamycin (mTOR) pathway in EC cells, thereby suppressing EC cell proliferation as well as migration in vitro. In conclusion, Dezocine inhibits proliferation as well as migration of EC in vitro.
Endometrial cancer (EC); Dezocine; Apoptosis; Proliferation; Akt/mTOR pathway
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