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Original Research

Open Access

Effects of Sufentanil on proliferation, migration and epithelial-mesenchymal transition of endometrial cancer

  • Chen Cheng1
  • Mimi Dai2,*,
  • Shishi Zheng1
  • Yujie Wu1
  • Li Shu2
  • Huimin Wu3

1Department of Pharmacy, The 2nd Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, Zhejiang, China

2Department of Obstetrics and Gynecology, The 2nd Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, Zhejiang, China

3Department of Anesthesiology, The 2nd Affiliated Hospital of Wenzhou Medical University, 325000 Wenzhou, Zhejiang, China

DOI: 10.22514/ejgo.2023.106 Vol.44,Issue 6,December 2023 pp.122-127

Submitted: 21 July 2023 Accepted: 25 August 2023

Published: 15 December 2023

*Corresponding Author(s): Mimi Dai E-mail: Daimimi_666@163.com

Abstract

To investigate the impact of Sufentanil on the progression of endometrial cancer (EC), including its proliferation, migration, epithelial-mesenchymal transition and underlying mechanism. The effects of Sufentanil on EC cell growth were evaluated using Cell counting kit-8 (CCK-8) and colony formation assays, while wound healing and transwell assays were performed to assess the influence on motility. In addition, immunoblot assays were performed to determine its role in EC cell epithelial-mesenchymal transition (EMT) and the associated underlying mechanism. Sufentanil demonstrated the ability to inhibit EC cell growth, migration, invasion and EMT process through the inhibition of the Protein Kinase B (AKT)/nuclear factor kappa-B (NF-κB) axis, thereby contributing to the repression of EC progression. Sufentanil effectively inhibited the proliferation, migration and EMT of endometrial cancer, demonstrating a potentially effective approach against EC.


Keywords

Endometrial cancer (EC); Sufentanil; Migration; EMT; AKT/NF-κB pathway


Cite and Share

Chen Cheng,Mimi Dai,Shishi Zheng,Yujie Wu,Li Shu,Huimin Wu. Effects of Sufentanil on proliferation, migration and epithelial-mesenchymal transition of endometrial cancer. European Journal of Gynaecological Oncology. 2023. 44(6);122-127.

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