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Original Research

Open Access

RTKN2, a potential target of breast cancer (BCa), can promote the growth and migration of breast cancer cells

  • Yantao Cai1
  • Wanting Bao1
  • Beili Zhang1,*,

1Department of General Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China

DOI: 10.22514/ejgo.2023.108 Vol.44,Issue 6,December 2023 pp.136-141

Submitted: 31 August 2023 Accepted: 07 October 2023

Published: 15 December 2023

*Corresponding Author(s): Beili Zhang E-mail:


Breast cancer (BCa) is a type of malignancy; however, the exact mechanisms responsible for breast cancer have yet to be elucidated. Rhotekin 2 (RTKN2) is a member of the Rhotekin family. Previous studies demonstrated that RTKN2 is highly expressed in numerous tumors. Previous analysis of the The cancer genome altas (TCGA) database demonstrated that PRKN2 was overexpressed in BCa. However, RTKN2 is rarely reported in BCa and the mechanisms remain unclear. The aim of this study was to elucidate the effect of RTKN2 on the growth of breast cancer cells and investigate the mechanisms involved. Our analysis revealed high expression of RTKN2 in human BCa. The depletion of RTKN2 suppressed the growth of breast cancer cells. In addition, the knockout of RTKN2 restrained the progression of BCa. We also revealed that the knockdown of RTKN2 stimulated cell cycle arrest in BCa. Mechanistically, RTKN2 mediated the Wnt/β-catenin axis to affect the progression of breast cancer. In conclusion, RTKN2 promotes the growth and migration of breast cancer cells by mediating the Wnt/β-catenin axis.


Rhotekin 2 (RTKN2); Breast cancer (BCa); Motility; Cell cycle; Wnt/β-catenin axis

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Yantao Cai,Wanting Bao,Beili Zhang. RTKN2, a potential target of breast cancer (BCa), can promote the growth and migration of breast cancer cells. European Journal of Gynaecological Oncology. 2023. 44(6);136-141.


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