Article Data

  • Views 760
  • Dowloads 141

Case Reports

Open Access

Comments on the definition of ovarian cancer stage IC2, related to fertility-sparing treatment

  • Nastasia Şerban1,2,*,
  • Savu Ana-Cătălina2
  • Duţescu Camelia3
  • Russu Manuela Cristina1,2

1“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania

2Department of Obstetrics and Gynecology, “Dr. Ion Cantacuzino” Clinical Hospital, 030167 Bucharest, Romania

3Department of Obstetrics and Gynecology, “Regina Maria” Hospital, 010107 Bucharest, Romania

DOI: 10.22514/ejgo.2023.111 Vol.44,Issue 6,December 2023 pp.157-162

Submitted: 26 April 2023 Accepted: 29 June 2023

Published: 15 December 2023

*Corresponding Author(s): Nastasia Şerban E-mail: serban.nastasia@umfcd.ro

Abstract

Fertility preservation is a significant concern in young patients with ovarian cancer due to its impact on the quality of life. Fertility-sparing surgery (FSS) in patients with epithelial ovarian cancer (EOC) should be reserved for those with stage IA disease. This article presents a patient diagnosed with stage IC2 endometrioid adenocarcinoma of the ovary who underwent FSS, subsequently became pregnant, and delivered a healthy baby. The favorable disease progression suggests a less aggressive nature, raising questions about the clarity of the International Federation of Gynecology and Obstetrics (FIGO) definition for stage IC2, specifically regarding the distinction between the presence of a tumor and the presence of invasive tumor on the ovarian surface. The clinical significance of differentiating between the presence and absence of invasive tumor on the ovarian surface requires further investigation. If deemed important, recognizing the absence of invasive tumor on the ovarian surface may lead to the classification of more cases as stages lower than IC, consequently increasing the utilization of fertility-sparing procedures.


Keywords

Ovarian cancer; Fertility-sparing surgery; FIGO classification of ovarian cancer


Cite and Share

Nastasia Şerban,Savu Ana-Cătălina,Duţescu Camelia,Russu Manuela Cristina. Comments on the definition of ovarian cancer stage IC2, related to fertility-sparing treatment. European Journal of Gynaecological Oncology. 2023. 44(6);157-162.

References

[1] Cancer Research UK. Ovarian cancer statistics UK. 2016 Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/ovarian-cancer#heading-Zero (Accessed: 26 November 2022).

[2] Kosary CL. Cancer of the ovary. In: SEER Cancer Statistics Review, 1975–2006, National Cancer Institute. 2009. Available at: https://seer.cancer.gov/csr/1975_2006/ (Accessed: 26 November 2022).

[3] Jones MR, Kamara D, Karlan BY, Pharoah PDP, Gayther SA. Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction. Gynecologic Oncology. 2017; 147: 705–713.

[4] Kwon Y, Hahn H, Kim T, Lee I, Lim K, Lee K, et al. Fertility preservation in patients with early epithelial ovarian cancer. Journal of Gynecologic Oncology. 2009; 20: 44–47.

[5] Ratanasrithong P, Benjapibal M. Pregnancy outcomes after conservative surgery for early-stage ovarian neoplasms. Asian Pacific Journal of Cancer Prevention. 2017; 18: 2083–2087.

[6] Anchezar JP, Sardi J, Soderini A. Long-term follow-up results of fertility sparing surgery in patients with epithelial ovarian cancer. Journal of Surgical Oncology. 2009; 100: 55–58.

[7] Tamauchi S, Kajiyama H, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, et al. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. American Journal of Obstetrics and Gynecology. 2018; 219: 385.e1–385.e7.

[8] Arend R, Holland A, St Clair C, Herzog TJ. Fertility preservation in ovarian cancer. Therapy. 2010; 7: 257–267.

[9] Morice P, Leblanc E, Rey A, Baron M, Querleu D, Blanchot J, et al. GCCLCC and SFOG. Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Francaise d’Oncologie Gynécologique). Human Reproduction. 2005; 20: 1379–1385.

[10] Gaughran J, Rosen O’Sullivan H, Lyne T, Abdelbar A, Abdalla M, et al. Fertility preserving surgery outcomes for ovarian malignancy: data from a tertiary cancer centre in central London. Journal of Clinical Medicine. 2022; 11: 3195.

[11] College of American Pathologists. Protocol for the examination of specimens from patients with primary tumors of the ovary, fallopian tube, or peritoneum. 2021. Available at: https://documents.cap.org/protocols/Ovary_FT_Perit_1.3.0.1.REL_CAPCP.pdf (Accessed: 26 November 2022).

[12] Seidman JD, Kurman RJ. Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. Human Pathology. 2000; 31: 539–557.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top