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Comments on the definition of ovarian cancer stage IC2, related to fertility-sparing treatment

  • Nastasia Şerban1,2,*,
  • Savu Ana-Cătălina2
  • Duţescu Camelia3
  • Russu Manuela Cristina1,2

1“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania

2Department of Obstetrics and Gynecology, “Dr. Ion Cantacuzino” Clinical Hospital, 030167 Bucharest, Romania

3Department of Obstetrics and Gynecology, “Regina Maria” Hospital, 010107 Bucharest, Romania

DOI: 10.22514/ejgo.2023.111 Vol.44,Issue 6,December 2023 pp.157-162

Submitted: 26 April 2023 Accepted: 29 June 2023

Published: 15 December 2023

*Corresponding Author(s): Nastasia Şerban E-mail:


Fertility preservation is a significant concern in young patients with ovarian cancer due to its impact on the quality of life. Fertility-sparing surgery (FSS) in patients with epithelial ovarian cancer (EOC) should be reserved for those with stage IA disease. This article presents a patient diagnosed with stage IC2 endometrioid adenocarcinoma of the ovary who underwent FSS, subsequently became pregnant, and delivered a healthy baby. The favorable disease progression suggests a less aggressive nature, raising questions about the clarity of the International Federation of Gynecology and Obstetrics (FIGO) definition for stage IC2, specifically regarding the distinction between the presence of a tumor and the presence of invasive tumor on the ovarian surface. The clinical significance of differentiating between the presence and absence of invasive tumor on the ovarian surface requires further investigation. If deemed important, recognizing the absence of invasive tumor on the ovarian surface may lead to the classification of more cases as stages lower than IC, consequently increasing the utilization of fertility-sparing procedures.


Ovarian cancer; Fertility-sparing surgery; FIGO classification of ovarian cancer

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Nastasia Şerban,Savu Ana-Cătălina,Duţescu Camelia,Russu Manuela Cristina. Comments on the definition of ovarian cancer stage IC2, related to fertility-sparing treatment. European Journal of Gynaecological Oncology. 2023. 44(6);157-162.


[1] Cancer Research UK. Ovarian cancer statistics UK. 2016 Available at: (Accessed: 26 November 2022).

[2] Kosary CL. Cancer of the ovary. In: SEER Cancer Statistics Review, 1975–2006, National Cancer Institute. 2009. Available at: (Accessed: 26 November 2022).

[3] Jones MR, Kamara D, Karlan BY, Pharoah PDP, Gayther SA. Genetic epidemiology of ovarian cancer and prospects for polygenic risk prediction. Gynecologic Oncology. 2017; 147: 705–713.

[4] Kwon Y, Hahn H, Kim T, Lee I, Lim K, Lee K, et al. Fertility preservation in patients with early epithelial ovarian cancer. Journal of Gynecologic Oncology. 2009; 20: 44–47.

[5] Ratanasrithong P, Benjapibal M. Pregnancy outcomes after conservative surgery for early-stage ovarian neoplasms. Asian Pacific Journal of Cancer Prevention. 2017; 18: 2083–2087.

[6] Anchezar JP, Sardi J, Soderini A. Long-term follow-up results of fertility sparing surgery in patients with epithelial ovarian cancer. Journal of Surgical Oncology. 2009; 100: 55–58.

[7] Tamauchi S, Kajiyama H, Yoshihara M, Ikeda Y, Yoshikawa N, Nishino K, et al. Reproductive outcomes of 105 malignant ovarian germ cell tumor survivors: a multicenter study. American Journal of Obstetrics and Gynecology. 2018; 219: 385.e1–385.e7.

[8] Arend R, Holland A, St Clair C, Herzog TJ. Fertility preservation in ovarian cancer. Therapy. 2010; 7: 257–267.

[9] Morice P, Leblanc E, Rey A, Baron M, Querleu D, Blanchot J, et al. GCCLCC and SFOG. Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Francaise d’Oncologie Gynécologique). Human Reproduction. 2005; 20: 1379–1385.

[10] Gaughran J, Rosen O’Sullivan H, Lyne T, Abdelbar A, Abdalla M, et al. Fertility preserving surgery outcomes for ovarian malignancy: data from a tertiary cancer centre in central London. Journal of Clinical Medicine. 2022; 11: 3195.

[11] College of American Pathologists. Protocol for the examination of specimens from patients with primary tumors of the ovary, fallopian tube, or peritoneum. 2021. Available at: (Accessed: 26 November 2022).

[12] Seidman JD, Kurman RJ. Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. Human Pathology. 2000; 31: 539–557.

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