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Original Research

Open Access

Taraxasterol stimulates apoptosis of BCa cells via restraining PI3K/AKT and epidermal growth factor receptor (EGFR)

  • Yanjun Hu1
  • Xiping Zhang1,*,
  • Shuai Zhao1

1Department of breast surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, 310022 Hangzhou, Zhejiang, China

DOI: 10.22514/ejgo.2024.007 Vol.45,Issue 1,February 2024 pp.42-49

Submitted: 31 August 2023 Accepted: 26 October 2023

Published: 15 February 2024

*Corresponding Author(s): Xiping Zhang E-mail: zhangxiping3083001@163.com

Abstract

Breast cancer (BCa) is a prevalent form of tumor, necessitating the development of more effective therapeutic drugs to improve patient prognosis. Taraxasterol (TAX), derived from the dandelion plant, has demonstrated significant physiological and pharmacological activity, but its role in BCa and underlying mechanism remains unexplored. In this study, we investigate the effects of TAX on the growth, motility and apoptosis of BCa cells in vitro to determine its mechanistic actions. Our results demonstrate that TAX significantly reduces both the proliferation and motility of BCa cells and induces apoptosis in BCa cells, as confirmed through flow cytometry (FCM). This apoptotic effect was further supported by JC-1 staining, which showed alterations in mitochondrial membrane potential in BCa cells after TAX treatment. Mechanistically, TAX suppresses the phosphatidylinositide 3-kinases/protein kinase B (PI3K/AKT) and EGFR pathways and impedes BCa progression. Collectively, TAX stimulates BCa cell apoptosis by inhibiting the PI3K/AKT and EGFR pathways.


Keywords

BCa; Taraxasterol (TAX); Apoptosis; Mitochondrial membrane potential; PI3K/AKT


Cite and Share

Yanjun Hu,Xiping Zhang,Shuai Zhao. Taraxasterol stimulates apoptosis of BCa cells via restraining PI3K/AKT and epidermal growth factor receptor (EGFR). European Journal of Gynaecological Oncology. 2024. 45(1);42-49.

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