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Original Research

Open Access

Comparison of biopsy results between two groups of cytology-negative HPV 16/18 and other types of high-risk HPV positive patients

  • Fatemeh Sadat Najib1,†
  • Marzieh Hashemi2,*,†,
  • Seyed Mohammad Amin Alavi3,*,†,
  • Zahra Shiravani2,†
  • Mojgan Akbarzadeh Jahromi4,†
  • Seyedeh Marjan Hosseini2,†

1Infertility Research Center, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, 1433671348 Shiraz, Iran

2Gynecology Oncology Division, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, 1433671348 Shiraz, Iran

3Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, 6135715794 Ahvaz, Iran

4Maternal-Fetal Medicine Research Center, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, 1433671348 Shiraz, Iran

DOI: 10.22514/ejgo.2024.008 Vol.45,Issue 1,February 2024 pp.50-54

Submitted: 02 April 2023 Accepted: 30 May 2023

Published: 15 February 2024

*Corresponding Author(s): Marzieh Hashemi E-mail: hashemimarzieh58@gmail.com
*Corresponding Author(s): Seyed Mohammad Amin Alavi E-mail: alavi.sma@ajums.ac.ir

† These authors contributed equally.

Abstract

Cervical cancer is the fourth most common cancer among women worldwide. It is believed that Human Papilloma Virus (HPV) is responsible for 100% of cervical cancers. 200 HPV genotypes have been identified to date, of which 13–15 are high-risk HPV genotypes infecting the genital area. 218 females suffering from high-risk HPV infection and showing a negative cytology test were selected in a retrospective cross-sectional study and divided into two groups: 1. HPV 16/18 (121 women) and 2. Other high-risk HPV (OHrHPV) (97 women). The demographic and clinical data were collected from Motahari clinic, Shiraz University of Medical Sciences, between September 2020 and January 2023. The collected data were analyzed using IBM SPSS software version 26. Data analysis was carried out using chi-square, t-test, and Mann-Whitney, and p < 0.05 was defined as being statistically significant for all the aforementioned tests. The mean age for the HPV 16/18 and OHrHPV groups were 35.27 ± 7.698 and 36.58 ± 8.756, respectively. The most prevalent HPV genotype was HPV type 16 (n = 96) in the population, followed by HPV type 18 (n = 25) and HPV type 31 (n = 17). The HPV 16/18 group had 15 high-grade colposcopy results, while only four similar results were observed in the OHrHPV group (p value = 0.031). The most prevalent HPV genotype in patients with cervical intraepithelial neoplasia (CIN) 2 and CIN3 was HPV16. The cytology test failed to identify over 4% of the lesions in the OHrHPV group. Direct referral for colposcopy in the OHrHPV group results in the identification of missed diagnosed lesions and lost to follow-up patients.


Keywords

Uterine cervical neoplasms; Human papillomavirus viruses; Colposcopy; Papanicolaou test


Cite and Share

Fatemeh Sadat Najib,Marzieh Hashemi,Seyed Mohammad Amin Alavi,Zahra Shiravani,Mojgan Akbarzadeh Jahromi,Seyedeh Marjan Hosseini. Comparison of biopsy results between two groups of cytology-negative HPV 16/18 and other types of high-risk HPV positive patients. European Journal of Gynaecological Oncology. 2024. 45(1);50-54.

References

[1] Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2021; 71: 209–249.

[2] World Health Organization (WHO). Cervical cancer. 2022. Available at: https://www.who.int/news-room/fact-sheets/detail/cervical-cancer (Accessed: 11 November 2022).

[3] Aker SŞ, Bakırarar B, Tinelli A, Ortaç F. The effect of other high-risk HPV types on cervical intraepithelial neoplasia and cancer. European Journal of Gynaecological Oncology. 2022; 43: 10–16.

[4] Malik ZA, Hailpern SM, Burk RD. Predictors of seropositivity to human papillomavirus type 53: one of the most prevalent high risk-related cervical human papillomaviruses. Viral Immunology. 2008; 21: 371–378.

[5] Park E, Kim JY, Choi S, Kim DS, Oh YL. Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea. Scientific Reports. 2019; 9: 12556.

[6] Muñoz N, Bosch FX, de Sanjosé S, Herrero R, Castellsagué X, Shah KV, et al.; International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. Epidemiologic classification of human papillomavirus types associated with cervical cancer. The New England Journal of Medicine. 2003; 48: 518–527.

[7] Tornesello ML, Buonaguro L, Izzo S, Lopez G, Vega X, Maldonado Reyes CF, et al. A pilot study on the distribution of human papillomavirus genotypes and HPV-16 variants in cervical neoplastic lesions from Ecuadorian women. Infectious Agents and Cancer. 2009; 4: P11.

[8] Jiang L, Tian X, Peng D, Zhang L, Xie F, Bi C, et al. HPV prevalence and genotype distribution among women in Shandong Province, China: analysis of 94,489 HPV genotyping results from Shandong’s largest independent pathology laboratory. PLOS ONE. 2019; 14: e0210311.

[9] Molina-Pineda A, López-Cardona MG, Limón-Toledo LP, Cantón-Romero JC, Martínez-Silva MG, Ramos-Sánchez HV, et al. High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico. BMC Infectious Diseases. 2020; 20: 889.

[10] Barut MU, Yildirim E, Kahraman M, Bozkurt M, Imirzalioğlu N, Kubar A, et al. Human papilloma viruses and their genotype distribution in women with high socioeconomic status in Central Anatolia, Turkey: a pilot study. Medical Science Monitor. 2018; 24: 58–66.

[11] Fontham ETH, Wolf AMD, Church TR, Etzioni R, Flowers CR, Herzig A, et al. Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society. CA: A Cancer Journal for Clinicians. 2020; 70: 321–346.

[12] Kremer WW, Steenbergen R, Heideman D, Kenter GG, Meijer C. The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review. BJOG. 2021; 128: 504–514.

[13] Vural NA, Köyan GN, Karadeniz O, Erdoğan Durmuş Ş, Kocaman Ö, Turan H. Comparison of colposcopic biopsy results of non-HPV 16/18 oncogenic type positive patients. Cam and Sakura Medical Journal. 2021; 1: 64–68.

[14] Aydın S, Öncü HN, Arıcı DS. Diagnostic performance of immediate colposcopy among women with high-risk human papillomavirus (HPV) other than HPV 16/18 and normal cytology. The Journal of Obstetrics and Gynaecology Research. 2021; 47: 720–725.

[15] Herraez-Hernandez E, Alvarez-Perez M, Navarro-Bustos G, Esquivias J, Alonso S, Aneiros-Fernandez J, et al. HPV direct flow CHIP: a new human papillomavirus genotyping method based on direct PCR from crude-cell extracts. Journal of Virological Methods. 2013; 193: 9–17.

[16] Nayar R, Wilbur DC. The pap test and Bethesda 2014. Cancer Cytopathology. 2015; 123: 271–281.

[17] Wang X, Wu S, Li Y. Risks for cervical abnormalities in women with non-16/18 high-risk human papillomavirus infections in south Shanghai, China. Journal of Medical Virology. 2021; 93: 6355–6361.

[18] Monsonego J, Cox JT, Behrens C, Sandri M, Franco EL, Yap P, et al. Prevalence of high-risk human papilloma virus genotypes and associated risk of cervical precancerous lesions in a large U.S. screening population: data from the ATHENA trial. Gynecologic Oncology. 2015; 137: 47–54.

[19] Bruni L, Diaz M, Castellsagué X, Ferrer E, Bosch FX, de Sanjosé S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. The Journal of Infectious Diseases. 2010; 202: 1789–1799.

[20] Dursun P, Ayhan A, Mutlu L, Çağlar M, Haberal A, Güngör T, et al. HPV types in Turkey: multicenter hospital based evaluation of 6388 patients in Turkish gynecologic oncology group centers. Turkish Journal of Pathology. 2013; 29: 210–216.

[21] Koyuncu K, Kurt M, Sakin Ö, Akalın EE, Denizli R, Öktem A, et al. Comparison of biopsy results of HPV 16/18 and non-16/18 HPV positive patients with a normal PAP test, a tertiary center experience. Journal of Surgery and Medicine. 2021; 5: 41–45.

[22] Aydoğmuş H, Aydoğmuş S. Comparison of colposcopic biopsy results of patients who have cytomorphological normal but HPV 16–18 or other high-risk HPV subtypes positive. Asian Pacific Journal of Cancer Prevention. 2019; 20: 417–420.

[23] Tainio K, Athanasiou A, Tikkinen KAO, Aaltonen R, Cárdenas J, Hernándes, et al. Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis. BMJ. 2018; 360: k499.

[24] Rijkaart DC, Berkhof J, van Kemenade FJ, Coupe VMH, Rozendaal L, Heideman DAM, et al. HPV DNA testing in population-based cervical screening (VUSA-Screen study): results and implications. British Journal of Cancer. 2012; 106: 975–981.

[25] Rijkaart DC, Berkhof J, van Kemenade FJ, Coupe VMH, Hesselink AT, Rozendaal L, et al. Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screening. International Journal of Cancer. 2012; 130: 602–610.

[26] Thrall MJ, Russell DK, Facik MS, Yao JL, Warner JN, Bonfiglio TA, et al. High-risk HPV testing in women 30 years or older with negative Papanicolaou tests: initial clinical experience with 18-month follow-up. American Journal of Clinical Pathology. 2010; 133: 894–898.

[27] Baser E, Togrul C, Ozgu E, Esercan A, Caglar M, Gungor T. Effect of pre-procedural state-trait anxiety on pain perception and discomfort in women undergoing colposcopy for cervical cytological abnormalities. Asian Pacific Journal of Cancer Prevention. 2013; 14: 4053–4056.


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