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Original Research

Open Access

Construction of a risk prediction model based on the analysis of MRI imaging features for patients with triple-negative breast cancer and validation of its efficacy

  • Cheng Che1
  • Cheng Zhou1
  • Yujun Niu1,*,

1Department of Radiology, The First Affiliated Hospital of Jinzhou Medical University, 121001 Jinzhou, Liaoning, China

DOI: 10.22514/ejgo.2024.012 Vol.45,Issue 1,February 2024 pp.76-82

Submitted: 28 July 2023 Accepted: 10 October 2023

Published: 15 February 2024

*Corresponding Author(s): Yujun Niu E-mail: Niuyujun_666@163.com

Abstract

This study is aimed at constructing a risk prediction model for patients with triple-negative breast cancer based on the feature analysis of Magnetic Resonance Imaging (MRI) and verifying the efficacy of the model. 150 patients admitted to our hospital, who had been diagnosed with breast cancer by immunohistochemistry were recruited as our study subjects. For each patient, we collated a range of clinical data (age, tumor size, menopausal status and family history of breast cancer), pathological findings (tumor pathological type and grading), and MRI imaging characteristics. Then patients with triple-negative breast cancer were compared to patients with non-triple-negative cancers. We created a risk prediction model for patients with triple-negative breast cancer after identifying risk variables for the disease using single-factor and multi-factor logistic regression analysis. The Hosmer and Lemeshow test was used to assess the goodness-of-fit of the risk prediction model and a Receiver Operating Characteristic (ROC) curve was plotted by SPSS to evaluate the predictive value of the risk prediction model. The results of single factor analysis based on MRI imaging characteristics showed that there were statistically significant differences between triple-negative breast cancer patients and non-triple-negative breast cancer patients in terms of clear boundaries, increased blood vessels around the tumor, T2-weighted imaging (T2WI) signals, and enhancement mode (p < 0.05). The statistical model for predicting triple-negative breast cancer was: P = 1/[1 + exp(6.055 − 2.802X2 − 1.904X3 − 2.120X4)]. The Hosmer and Lemeshow test was used to test the goodness-of-fit for the statistical model (χ2 = 7.993, p = 0.434). ROC analysis showed that the area under the curve (AUC) was 0.916 and with a 95%confidence interval (CI) of 0.874–0.957.


Keywords

MRI imaging features; Triple-negative breast cancer patients; Risk prediction model; Efficacy verification


Cite and Share

Cheng Che,Cheng Zhou,Yujun Niu. Construction of a risk prediction model based on the analysis of MRI imaging features for patients with triple-negative breast cancer and validation of its efficacy. European Journal of Gynaecological Oncology. 2024. 45(1);76-82.

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