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Original Research

Open Access

Magnoflorine inhibits cisplatin-induced protective autophagy by down-regulating HMGB1 and increases drug sensitivity in drug-resistant ovarian cancer cells

  • Yiling Zhang1,†
  • Xin He2,†
  • Lei Fan3,*,
  • Qianru Zhang4,*,

1Department of Oncology, Xi’an Daxing Hospital, 710016 Xi’an, Shaanxi, China

2Department of Oncology, Tangdu Hospital, Air Force Medical University, 710038 Xi’an, Shaanxi, China

3Department of Pharmacy, The Second Affiliated Hospital of Zhejiang Chinese Medical University, 310005 Hangzhou, Zhejiang, China

4Department of Pharmacy, Xi’an Daxing Hospital, 710016 Xi’an, Shaanxi, China

DOI: 10.22514/ejgo.2024.018 Vol.45,Issue 1,February 2024 pp.132-138

Submitted: 07 October 2023 Accepted: 29 November 2023

Published: 15 February 2024

*Corresponding Author(s): Lei Fan E-mail:
*Corresponding Author(s): Qianru Zhang E-mail:

† These authors contributed equally.


Ovarian cancer (OC) is a prevalent type of gynecologic malignancy, and to improve its treatment effectiveness, it is essential to identify new and more potent therapeutic drugs. Magnoflorine is a fundamental chlorine alkaloid with various pharmacological properties, including anti-diabetic and anti-inflammatory effects. However, whether Magnoflorine can inhibit the protective autophagy induced by cisplatin by modulating (high-mobility group B1) HMGB1 requires further investigation. This study aims to assess the impact of Magnoflorine on cisplatin resistance in OC. Our findings demonstrate that Magnoflorine enhances the sensitivity of OC cells to cisplatin. Additionally, it promotes apoptosis in cisplatin-resistant OC cells and simultaneously inhibits cisplatin-induced protective autophagy. Mechanistically, Magnoflorine reduces HMGB1 expression in cisplatin-resistant OC cells. Collectively, these results suggest that Magnoflorine has potential as a therapeutic agent for cisplatin-resistant OC in future clinical applications.


Ovarian cancer; Cisplatin; Apoptosis; Autophagy; HMGB1

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Yiling Zhang,Xin He,Lei Fan,Qianru Zhang. Magnoflorine inhibits cisplatin-induced protective autophagy by down-regulating HMGB1 and increases drug sensitivity in drug-resistant ovarian cancer cells. European Journal of Gynaecological Oncology. 2024. 45(1);132-138.


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