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Original Research

Open Access

A comparative study on myomectomy and total hysterectomy in the treatment of perimenopausal uterine fibroids

  • Jing Zeng1
  • Jing Wang1
  • Min Wang1
  • Xiaoli Wang1,*,

1Department of Gynecology and Obstetrics, Chengdu Second People’s Hospital, 610017 Chengdu, Sichuan, China

DOI: 10.22514/ejgo.2024.036 Vol.45,Issue 2,April 2024 pp.141-146

Submitted: 21 December 2023 Accepted: 21 January 2024

Published: 15 April 2024

*Corresponding Author(s): Xiaoli Wang E-mail:


This study aims to compare the clinical efficacy of myomectomy and total hysterectomy in the treatment of perimenopausal uterine fibroids. 124 cases of uterine fibroids were randomly divided into a control group and a study group, each with 62 cases. The control group underwent a total hysterectomy. Study participants underwent a myomectomy. Both groups of patients were observed and compared for surgery-related indicators, quality of life scores, perimenopausal syndrome and inflammatory factors. The study group had a shorter operation time and less intraoperative blood loss (p < 0.05). Before operation, there was no significant difference in Quality of life Short Form 36 (SF-36) score, Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and IL-10 between both groups (p > 0.05) at 6 months after operation, SF-36 score in both groups were higher than before operation, and IL-6, TNF-α and IL-10 in both groups were higher than before operation (p < 0.05). Perimenopausal syndrome incidence was significantly lower in the study group than in the control group (p < 0.05). Myomectomy is more suitable for treating perimenopausal uterine fibroids.


Myomectomy; Total hysterectomy; Perimenopausal period; Uterine fibroids

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Jing Zeng,Jing Wang,Min Wang,Xiaoli Wang. A comparative study on myomectomy and total hysterectomy in the treatment of perimenopausal uterine fibroids. European Journal of Gynaecological Oncology. 2024. 45(2);141-146.


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