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Original Research

Open Access

Metabolism related gene signature predicts prognosis and indicates tumor immune infiltration in ovarian cancer

  • Yaodong Zhang1,†
  • Xuenan Zhao2,†
  • Huilan Qiu1,†
  • Xia Chen3
  • Zhongwei Zhang1
  • Biao Zhu1
  • Liwen Bu4,5,*,
  • Zuguang Xia6,*,

1Department of Critical Care, Fudan University Shanghai Cancer Center, 200032 Shanghai, China

2Department of Urology, Fudan University Shanghai Cancer Center, 200032 Shanghai, China

3Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 200001 Shanghai, China

4Department of Nursing Administration, Fudan University Shanghai Cancer Center, 200032 Shanghai, China

5Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 200032 Shanghai, China

6Department of Medical Oncology, Fudan University Shanghai Cancer Center, 200032 Shanghai, China

DOI: 10.22514/ejgo.2024.040

Submitted: 11 May 2023 Accepted: 10 August 2023

Online publish date: 17 April 2024

*Corresponding Author(s): Liwen Bu E-mail: boliwen68@shca.org.cn
*Corresponding Author(s): Zuguang Xia E-mail: xiazg@shca.org.cn

† These authors contributed equally.

Abstract

Energy metabolism plays a crucial role in supporting cancer cell growth and driving tumor progression. Our objective was to create a unique gene signature based on metabolic genes that could accurately predict the prognosis of patients with ovarian cancer (OC). We accessed microarray data of patients with OC from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Patients from the TCGA dataset were divided into training and internal validation sets, maintaining a ratio of 3:1. Based on Least absolute shrinkage and selection operator Cox regression analysis, twenty-nine metabolism-related genes were identified for the development of the metabolic signature. Patients in the training set were successfully divided into low-and high-risk groups with a significantly different prognosis (Hazard Ratio (HR): 2.76, 95% Confidence Interval (CI): 2.12–3.59, p < 0.001). The prognostic value of this signature was confirmed in the internal (HR: 3.06, 95% CI: 1.80–5.17, p < 0.001) and external validation sets (HR: 2.17, 95% CI: 1.57–2.99, p < 0.001). The time-dependent receiver operating characteristic (ROC) at the 5-year interval demonstrated that the prognostic accuracy of this metabolic signature (Area under curve (AUC) = 0.723) was superior to that of any other clinicopathological features, including the Federation of Gynecology and Obstetrics stage (AUC = 0.509), grade (AUC = 0.536), and debulking status (AUC = 0.637). Further immune cell infiltration analysis showed that low-risk patients had a higher enrichment of immune-activating cells. In conclusion, a novel metabolic signature with good performance was established in this study. This prognostic model could aid in the identification of high-risk patients who require aggressive follow-up and therapeutic strategies.


Keywords

Ovarian cancer; TCGA; GEO; Metabolism; Prognosis


Cite and Share

Yaodong Zhang,Xuenan Zhao,Huilan Qiu,Xia Chen,Zhongwei Zhang,Biao Zhu,Liwen Bu,Zuguang Xia. Metabolism related gene signature predicts prognosis and indicates tumor immune infiltration in ovarian cancer. European Journal of Gynaecological Oncology. 2024.doi:10.22514/ejgo.2024.040.

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