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Original Research

Open Access

Taraxasterol inhibits cell proliferation and angiogenesis in ovarian cancer by targeting EphA2

  • Chunhui Wang1,*,
  • Suwei Lan1
  • Bing Han1
  • Xingcha Wang1

1Department of Gynecology, Affiliated Hospital of Chengde medical university, 067000 Chengde, Hebei, China

DOI: 10.22514/ejgo.2024.049 Vol.45,Issue 3,June 2024 pp.62-67

Submitted: 29 January 2024 Accepted: 29 February 2024

Published: 15 June 2024

*Corresponding Author(s): Chunhui Wang E-mail: chunhui1233@163.com

Abstract

Ovarian Cancer (OC) is a prevalent gynecological malignancy, underscoring the urgency to discover novel therapeutic approaches that enhance both clinical efficacy and safety. Taraxasterol (TA), an important component of dandelion, has been reported to exhibit inhibitory effects on the progression of various tumors. However, its specific role in OC is yet to be reported. In this present study, we observed that TA significantly inhibits the proliferation of OC cells, promotes apoptosis and reduces OC cell migration and angiogenesis. Mechanistically, TA targets the EPH receptor A2 (EphA2) receptor, thereby inhibiting OC progression. In conclusion, the ability of TA to suppress both cell proliferation and angiogenesis in OC through EphA2 targeting suggests its potential utility as a therapeutic agent for OC.


Keywords

Taraxasterol (TA); Ovarian cancer (OC); Apoptosis; Angiogenesis; EPH receptor A2 (EphA2)


Cite and Share

Chunhui Wang,Suwei Lan,Bing Han,Xingcha Wang. Taraxasterol inhibits cell proliferation and angiogenesis in ovarian cancer by targeting EphA2. European Journal of Gynaecological Oncology. 2024. 45(3);62-67.

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